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Ekhterae et al., Circ Res 1999
:
Loss of endogenous ARC in the cytosol of H9c2 cells was associated with translocation of ARC from the cytosol to intracellular membranes, release of cytochrome c from the mitochondria, activation of caspase-3 , poly ( ADP-ribose ) polymerase ( PARP ) cleavage, and DNA fragmentation
Hunter et al., FEBS Lett 2007
:
ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition