◀ Back to VIM
CASP3 — VIM
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Caspase Cascade in Apoptosis:
Vimentin (VIM)
→
Caspase 3 (CASP3)
(modification, collaborate)
Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
Caspase 3 (CASP3)
→
Vimentin fragment 4 (VIM)
(modification, activates)
Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
Caspase 3 (CASP3)
→
Vimentin fragment 3 (VIM)
(modification, activates)
Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
Evidence: assay, physical interaction
-
Reactome Reaction:
CASP3
→
VIM
(reaction)
Byun et al., Cell Death Differ 2001*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
VIM
—
CASP3
(direct interaction, enzymatic study)
Walsh et al., Proc Natl Acad Sci U S A 2008
-
IRef Hprd Interaction:
VIM
—
CASP3
(in vitro)
Morishima et al., Genes Cells 1999*, Byun et al., Cell Death Differ 2001*, Nakanishi et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
VIM
—
CASP3
(in vivo)
Morishima et al., Genes Cells 1999*, Byun et al., Cell Death Differ 2001*, Nakanishi et al., J Biol Chem 2001*
Text-mined interactions from Literome
Yang et al., Am J Pathol 2005
(Arthritis, Rheumatoid) :
Taken together, our findings suggest a unique
role for
caspase-4 in cleaving
vimentin and releasing cytosolic p53 for nuclear translocation, events that may regulate the sensitivity of RASFs to receptor mediated apoptosis
Catassi et al., Cell Mol Life Sci 2006
(Carcinoma, Non-Small-Cell Lung...) :
A cascade of events leading to apoptotic mitochondrial ` intrinsic ' pathway was observed in treated cells : ( 1 ) dephosphorylation of BAD serine136 ; ( 2 ) BAD dissociation from 14-3-3 followed by its association with BCL-XL ; ( 3 ) cytochrome c release ; ( 4 )
caspase-3 activation , and ( 5 ) cleavage of
vimentin
Lahat et al., PloS one 2010
(Neovascularization, Pathologic...) :
This proapoptotic response was abrogated after vimentin knockdown or by blockade of
caspase induced
vimentin degradation via caspase inhibitors or overexpression of mutated caspase-resistant vimentin