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CASP4 — TGFB1

Text-mined interactions from Literome

Shima et al., Hepatology 1999 (Carcinoma, Hepatocellular...) : Activation of caspase-8 in transforming growth factor-beta induced apoptosis of human hepatoma cells
Hishikawa et al., Eur J Pharmacol 1999 : Moreover, TGF-beta(1) activated caspase 3 in HASC, and the CTGF antisense oligonucleotide reduced this activation
Zhu et al., Neurochem Int 2001 : TGF-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures ... The present study attempted to identify whether TGF-beta1 can prevent neuronal apoptosis and interrupt caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment ... Furthermore, TGF-beta1 ( 1 and 10 ng/ml ) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting
Kim et al., Oncogene 2001 (Stomach Neoplasms) : Taken together, our results suggest that activation of caspase-3 by TGF-beta1 may initiate the conversion from G1 cell cycle arrest to apoptosis via the cleavage of p21, p27 and Rb, which in turn causes Cdk2 activation and, most significantly, Cdk2 activation as a downstream effector of caspase is a critical step for the execution of TGF-beta1 induced apoptosis
Cain et al., Toxicol Lett 2001 : However the mechanism by which TGF-beta(1) induces caspase activation and cell death is unknown
Hayashida-Hibino et al., Invest Ophthalmol Vis Sci 2001 : Furthermore, Western blot analysis revealed that TGF-beta1 remarkably decreased PAI-2, transferrin receptor, and integrin alpha3, and increased caspase10 on the protein level
Herrera et al., Hepatology 2001 : Our results show that TGF-beta1 activates at least caspase-3 , -8, and -9 in rat fetal hepatocytes, which are not required for ROS production, glutathione depletion, bcl-xL down-regulation, and initial cytochrome c release
Negulescu et al., Kidney Int 2002 : The effects of TGF-beta1 on mesangial cell apoptosis, p53 phosphorylation, Bax and Bcl-2 levels, caspase 9 activity, and cleavage of PARP were examined
Coyle et al., J Biol Chem 2003 (Carcinoma, Hepatocellular...) : We have previously shown that transforming growth factor-beta(1) ( TGF-beta(1) ) -induced apoptosis in FaO hepatoma cells is mediated by cytochrome c release, apoptosome formation, and caspase activation ... A second delayed response cluster ( 44 genes ) was also observed when TGF-beta(1) induced caspase activation was blocked by benzyloxycarbonyl-VAD-fluoromethyl ketone
Albright et al., Exp Mol Pathol 2003 (Cell Transformation, Viral) : TGFbeta1-apoptosis was significantly reduced when cells were treated with TGFbeta1 in the presence of inhibitors of caspase-1 , -3, -8, and -9
Kim et al., J Biol Chem 2004 (Carcinoma, Hepatocellular...) : In contrast, overexpression of the dominant negative MLK3 resulted in suppression of TGF-beta1 induced MAP kinase activation and TGF-beta1 induced caspase-3 activation
Wang et al., Carcinogenesis 2005 : This effect is dependent on RON expression and phosphorylation that inhibit the TGF-beta1 induced activation of caspase-3 and truncation of BAD ... PD98059 also prevented the inhibitory effect of RON on TGF-beta1 induced cleavage of caspase-3 and BAD
Guo et al., World J Gastroenterol 2005 : TGF-beta1 induced apoptosis was associated with the phosphorylation of p38, and SB202190, a specific inhibitor of p38, which was able to inhibit TGF-beta1 induced caspase activation and apoptosis
Kim et al., Exp Mol Med 2007 : TGF-beta1 induced early increase of caspase-3 activity
Nastiuk et al., Mol Cancer Res 2008 : TGFbeta1 induced caspase-3 activity is proportional to the level of cell death and inversely proportional to the level of FLIP expression in various clones
Park et al., Mol Carcinog 2008 (Carcinoma, Hepatocellular...) : The TGFbeta1 induced caspase-3 activation was also suppressed in Huh-7 and FaO cells both transduced with PTN gene bearing adenoviruses
Lu et al., Am J Physiol Lung Cell Mol Physiol 2009 : While caspase-12 activity was not altered, caspase-8 was activated by TGF-beta1 , an effect that correlated with a reduction of cFLIP protein levels
Houde et al., J Biol Chem 2009 : The expression of activated caspase-9 , but not that of caspase-8, was increased by TGF-beta1 stimulation, and the rate of TGF-beta1 induced apoptosis was significantly lower in the presence of a caspase-9 inhibitor
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : TSA prevented TGF-beta1 induced apoptosis and the activation of caspase-8 and caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )