Gene interactions and pathways from curated databases and text-mining

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CASP5 — SPP1

Text-mined interactions from Literome

Graessmann et al., Oncogene 2007 (Mammary Neoplasms, Animal) : In serum starved ME-A cells, the OPN containing ME-C cell medium prevents caspase-3 activation
Cuvillier et al., J Biol Chem 1998 : Thus, SPP , likely generated via protein kinase C-mediated activation of sphingosine kinase, suppresses the apoptotic pathway downstream of FLICE but upstream of the executioner caspases, caspase-3 , -6, and -7