Gene interactions and pathways from curated databases and text-mining

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CASP6 — PPARA

Text-mined interactions from Literome

Billiet et al., J Mol Biol 2008 : Finally, PPARalpha activation reduced the lidocaine induced caspase-3 activity and apoptosis, which might be due to the VDUP-1 mediated regulation of the Bax/Bcl-2 ratio
Chen et al., American journal of physiology. Renal physiology 2009 (Reperfusion Injury) : Overexpression of prostacyclin using an adenovirus could also induce PPAR-alpha translocation from the cytosol into the nucleus to inhibit caspase-3 activation
He et al., Zhongguo Fei Ai Za Zhi 2006 : Activated PPAR-? can increase caspase-3 activity to induce apoptosis of cells
Wang et al., Acta Diabetol 2013 : Additionally, the enhancement of PPAR? expression by treatment with TZDs inhibited the expression of caspase 3 in IL-1ß/IFN-? induced NIT-cells
Wang et al., Oncogene 2012 (Colorectal Neoplasms) : More importantly, the opposing effects of PPARd and PPAR? in regulating programmed cell death are mediated by survivin and caspase-3