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CBL — IRS2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 143 proteins (association, anti tag coimmunoprecipitation)

Text-mined interactions from Literome

Standaert et al., Endocrinology 2002 : Cbl , IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes
Miura et al., Biochemistry 2004 : We have also used these adipocytes to see if IRS-1 and IRS-2 are required for activation of Cbl , which is required for insulin stimulated glucose transport and has been found to function upstream of both PI3K/aPKC and Crk during thiazolidinedione action in 3T3/L1 adipocytes [ Miura et al. ( 2003 ) Biochemistry 42, 14335 ] ... These findings provide evidence that directly links both IRS-1 and IRS-2 to aPKC activation in immortalized brown adipocytes, and further suggest that IRS-1 and IRS-2 are required for the activation of Cbl/PI3K during insulin action in these cells