Gene interactions and pathways from curated databases and text-mining

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CCND1 — FHL2

Text-mined interactions from Literome

Labalette et al., J Biol Chem 2008 : The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation ... We show that deficiency of FHL2 greatly reduces the proliferative capacity of spontaneously immortalized mouse fibroblasts, which is associated with decreased expression of cyclin D1 and p16(INK4a), and hypophosphorylation of Rb. Reexpression of FHL2 in FHL2-null fibroblasts efficiently restores cyclin D1 levels and cell proliferative capacity, indicating that FHL2 is critical for cyclin D1 activation and cell growth
Labalette et al., PloS one 2008 : We reported previously that FHL2 regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts ( MEFs ) display reduced levels of cyclin D1 and low proliferative activity