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CD2 — IFNG

Text-mined interactions from Literome

Gonsky et al., J Immunol 2000 : Activation of LPMC via CD2 induced IFN-gamma secretion and a parallel up-regulation of mRNA expression
Meinl et al., J Immunol 2000 (Severe Combined Immunodeficiency) : CD2 induced proliferation as well as production of TNF-alpha and IFN-gamma was abrogated in ZAP-70-deficient T cells, whereas PMA plus ionomycin induced normal activation of these cells
Chaves et al., Eur J Immunol 2001 : Similarly, IL-4 but not IL-10 inhibited the cell surface expression of HLA-DR and CD2 induced by IFN-gamma
Musgrave et al., J Interferon Cytokine Res 2003 : Induction of nonspecific CTL and interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) synthesis were impaired in the absence of CD2-CD48 interactions ... We conclude that CD2-CD48 interactions during T cell activation are critical for the synthesis of sufficient IL-2 and IFN-gamma to drive CD8 ( + ) T cells to differentiate into functional cytotoxic effector cells
Visse et al., Biol Res 2003 : While both CD28/B7-1 and CD2/LFA-3 costimulation resulted in the up-regulation of IL-4 and IFN-gamma promoters, IL-2 promoter activity and production of IL-2 were only seen after B7-1 costimulation
Cohavy et al., J Immunol 2004 : Independent stimulation of the LIGHT receptor, herpesvirus entry mediator, induced IFN-gamma production in lamina propria T cells, while blocking LIGHT inhibited CD2 dependent induction of IFN-gamma synthesis, indicating a role for LIGHT in the regulation of IFN-gamma and as a putative mediator of proinflammatory T-T interactions in the intestinal mucosa
Musgrave et al., Cell Immunol 2004 : CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA
Gonsky et al., J Immunol 2004 : Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression ... CD2 signaling of human PBMC results in activation of the -3.6-kb IFN-gamma promoter, whereas mutation of the -3.6-kb STAT5 site attenuates promoter activity ... AG490, a tyrosine kinase inhibitor affecting Jak proteins, inhibits CD2 mediated IFN-gamma mRNA expression, secretion, and nucleoprotein binding to the IFN-gamma STAT5 site in a dose dependent fashion
Langhorst et al., Psychoneuroendocrinology 2007 (Colitis, Ulcerative) : Significant but comparable public speaking stress induced increases in LPS stimulated TNF-alpha and IL-10, as well as in CD2/CD28 stimulated IFN-gamma were observed in both groups
Burdach et al., Blood 1988 : In addition, CD2 blockade reduced interferon-gamma (IF gamma) release ( 84 to 128 U/mL ) from CD3 triggered T cells by 81 % at day 3 of culture
Weber et al., Brain 1994 (Multiple Sclerosis) : IFN-gamma alone or in combination with TNF-alpha strongly enhanced expression of HLA class I, HLA-DR, -DP, -DQ, LFA-1 alpha and ICAM-1, but did not affect expression of LFA-2 ( CD2 ) and LFA-3 ( CD58 )
Wingren et al., J Immunol 1993 : Monocyte regulated IFN-gamma production in human T cells involves CD2 signaling ... mAb blocking experiments suggested the involvement of the CD2/LFA-3 but not the LFA-1/ICAM-1 pathway in monocyte regulation of T cell synthesis of IFN-gamma
Monteleone et al., Gut 1998 (Colitis...) : In preactivated T-LPLs, IL-7 enhanced IFN-gamma release induced by both IL-12 and anti-CD2 , whereas IL-15 potentiated only IL-12 induced IFN-gamma synthesis