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CD28 — IFNG

Text-mined interactions from Literome

Zhang et al., J Immunol 1999 : T cell proliferation and production of IL-2, IL-4, and IFN-gamma induced by both CD3 and CD3/CD28 ligation and the nuclear expression of the c-Jun and ATF-2 proteins are each blocked by the p38 MAPK inhibitor SB203580
Walker et al., J Immunol 1999 : Similarly, although anti-CD28 stimulation alone could enhance IFN-gamma synthesis, this effect was significantly increased in the presence of IL-12 ... These findings illustrate costimulatory pathways that result in potent IFN-gamma responses by NK cells and show that although IL-18 and anti-CD28 can enhance the synthesis of IL-12-driven IFN-gamma , they employ molecular mechanisms that are distinct from one another
Tang et al., Cancer Lett 1999 (Carcinoma...) : Although expression of CD28 was shown to be decreased in TILs, expression of CD25 and IFN-gamma at a relatively high percentage could be consistently detected in the UNPC biopsies
Gelfanova et al., J Biomed Sci 1999 : Unlike lymph node CD4+ cells, the CD28 costimulation induced Th2 differentiation of CD4+ iIEL was not inhibited by IFN-gamma
Cheung et al., Mol Immunol 1999 : Using this assay we have also determined that immobilized anti-CD28 can not induce resting NK cells to produce IFN-gamma
Vijayakrishnan et al., J Immunol 2000 : Subsequent experiments revealed that IFN-gamma production from activated T cells resulted from an engagement of CD28 by B7-1 on the B cell surface
Subauste et al., J Immunol 2000 : IFN-gamma production in response to DC infected with viable parasites required CD28 and CD40 ligand (CD40L) signaling ... IL-12 independent IFN-gamma production required CD80/CD86-CD28 interaction and, to a lesser extent, CD40-CD40L signaling
Agarwal et al., J Interferon Cytokine Res 2000 : Role of CD28/B7 costimulation in the dexamethasone induced suppression of IFN-gamma ... Lastly, activation of CD28 with anti-CD28 antibody attenuated the Dex induced decrease in interferon-gamma (IFN-gamma) production by anti-CD3 antibody stimulated PBMC
Hombach et al., Cancer Res 2001 : Cross linking of recombinant receptors by solid-phase bound ligand, i.e., CD30 and a carcinoembryonic antigen receptor-specific anti-idiotypic antibody, respectively, induces IFN-gamma secretion that is further enhanced by CD28 costimulation of grafted T cells
Sadeghi et al., Int Immunopharmacol 2001 : In contrast, the ansamycin, geldanamycin, inhibited both IL-2 and IFN-gamma production induced by anti-CD3 and anti-CD28 or PMA and anti-CD28
Hombach et al., J Immunol 2001 : CD28 costimulation did not affect cytolysis by T cells equipped with gamma- or zeta signaling receptors, but enhanced both IFN-gamma secretion and proliferation
Venuprasad et al., J Immunol 2002 : Cross linking of neutrophil expressed CD28 by monoclonal anti-CD28 Ab or B7.1-Ig or B7.2-Ig results in phosphatidylinositol 3-kinase association with CD28 and in wortmannin-sensitive but cyclosporin A-resistant induction and secretion of IFN-gamma
McDyer et al., J Immunol 2002 : Similarly, IFN-gamma production at 6 h was CD28/IL-2 independent but CD28/IL-2 dependent and inhibited by HAT at 48 h
Shibuya et al., Clin Exp Immunol 2003 : By contrast, IFN-alpha by itself did not enhance IFN-gamma production or mRNA expression in CD4+ T cells in the absence of IL-12 even in the presence of stimulation with anti-CD28 , but enhanced it in the presence of IL-12
Wang et al., J Biol Chem 2003 : Our results show that morphine inhibited anti-CD3/CD28 stimulated IFN-gamma promoter activity in a dose dependent manner
van Roon et al., Arthritis Res Ther 2003 (Arthritis, Rheumatoid) : CD3/CD28 costimulation and IL-7 were early inducers of IL-4 production, but primarily stimulated IFN-gamma production
Fraser et al., Mol Cell Biol 1992 (Leukemia, T-Cell) : Stimulation of CD28 in the presence of TCR-like signals increases the activity of the GM-CSF, IL-3, and IFN-gamma promoters by three- to sixfold
Visse et al., Biol Res 2003 : While both CD28/B7-1 and CD2/LFA-3 costimulation resulted in the up-regulation of IL-4 and IFN-gamma promoters, IL-2 promoter activity and production of IL-2 were only seen after B7-1 costimulation
Musgrave et al., Cell Immunol 2004 : However, CD28 costimulation had a stronger enhancing effect on IL-2 and IFN-gamma mRNA stability that was not further increased by concomitant CD2 signaling
Orabona et al., Nat Immunol 2004 (Candidiasis...) : Here we show that mouse dendritic cells were induced by soluble CD28 to express interleukin 6 and interferon-gamma
Martins et al., Microbes Infect 2004 (Chagas Disease...) : CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection
Elias et al., J Immunol 2005 (Malaria...) : Production of IFN-gamma ; up-regulation of CD69, CD40L, CD95 ( Fas ), and CD95L ( Fas ligand ) ; and induction of apoptosis were also affected by the lack of CD28
Gao et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2005 (Hepatitis B, Chronic) : In patients effectively treated by BSR, after 3 months treatment, level of IFN-gamma in PBMC culture significantly increased , CD8+ CD28+ , CD28+ T-cells significantly enhanced and IL-10 and CD8 + CD28+ T-cells significantly decreased ( P < 0.05, P < 0.01 )
Wittmann et al., J Leukoc Biol 2006 : This increased IFN-gamma production is dependent on T cell receptor ( TCR ) and CD28 signaling as well as on the presence of IL-12
Yonkers et al., J Infect Dis 2006 (HIV Infections...) : We measured CD4- and CD8-specific interferon- gamma responses to hepatitis C virus ( HCV ) peptide pools in subjects with chronic HCV monoinfection ( n=14 ), in subjects with chronic HCV/HIV coinfection ( n=15 ), and in healthy control subjects ( n=10 ) by enzyme linked immunospot assay in the presence and absence of CD28 costimulation
Giorelli et al., Exp Neurol 2007 (Multiple Sclerosis) : Agonist induced activation of LXRs partially counteracts the anti-CD3+ anti-CD28 induced proliferation of T cells ( p < 0.01 ) and secretion of IFNgamma ( p < 0.001 ) from PBMCs of MS patients as well as of HC
Ersvaer et al., Hematology 2007 (Leukemia, Myeloid, Acute) : The in vitro interferon-gamma (IFNgamma) release in response to stimulation with anti-CD3 plus anti-CD28 in the presence of autologous AML cells was examined for 31 patients ... The T cells could be stimulated to release IFNgamma in response to anti-CD3 plus anti-CD28 ligation even in the presence of excess autologous AML blasts, and for a subset of patients ( 6 of 27 ) these IFNgamma levels could be further increased by the novel protein kinase C ( PKC ) agonist PEP005
Langhorst et al., Psychoneuroendocrinology 2007 (Colitis, Ulcerative) : Significant but comparable public speaking stress induced increases in LPS stimulated TNF-alpha and IL-10, as well as in CD2/CD28 stimulated IFN-gamma were observed in both groups
Papasavvas et al., AIDS Res Hum Retroviruses 2008 (HIV Infections...) : No difference among groups was observed for anti-CD3/CD28 mediated IFN-gamma responses
El-Tayeb et al., J Med Chem 2009 : The corresponding AMP derivative ( 12g ) was a similarly good substrate as AMP itself, while the resulting adenosine derivative ( 11g ) was a relatively potent A ( 2A ) agonist ( radioligand binding to rat brain striatal membranes : K ( i ) = 372 nM ; inhibition of anti-CD3/anti-CD28 induced IFN-gamma release in mouse CD4+ cells : EC ( 50 ) = 50 nM )
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Loza et al., Respir Res 2010 (Asthma) : An ex vivo system was used to characterize the regulation of IFN-gamma producing ( type 1 ) and IL-13 producing ( type 2 ) T cell accumulation in response to CD3+CD28 and IL-2 stimulation by flow cytometry
Nandi et al., J Immunol 1994 : IL-2 activated NK cells produced enhanced levels of IFN-gamma and TNF in response to stimulation with anti-CD28 and PMA
Dobber et al., Cell Immunol 1995 : This was not due to lack of CD28 triggering since anti-CD28 enhanced IFN-gamma as well as IL-4 and IL-10 to a similar extent
Shanafelt et al., J Immunol 1995 (Hypersensitivity, Immediate...) : CD28 mediated costimulatory signals induced proliferation and IFN-gamma secretion by Th1 cells
Goodman et al., J Immunol 1994 : Because keratinocytes express BB-1, a CD28-ligand distinct from B7-1 or B7-2 ( which are found on professional APCs ), we examined the possibility that the defect in IFN-gamma production might be a result of nonproductive CD28 engagement
Borger et al., J Immunol 1996 : However, IL-7 dose-dependently up-regulates the anti-CD3- or anti-CD3/anti-CD28 induced IFN-gamma and IL-4 mRNA expression
Fitch et al., Ciba Found Symp 1995 : Stimulation of CD28 together with TCR induces secretion of IL-2 and IFN-gamma , and cells proliferate without exogenous cytokines
Laihia et al., Arch Dermatol Res 1996 : CD80 expression was efficiently induced in monocytic ( CD14+ ) cells by human interferon-gamma , while CD28 levels on lymphocytes remained unchanged, as detected by flow cytometry
Freeman et al., Ann N Y Acad Sci 1996 (Hypertension, Portal...) : By contrast IFN-gamma production is augmented in the presence of anti-CD28 and decreased in the presence of anti-B7-2
McDyer et al., J Immunol 1998 : CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28 dependent manner ... We further studied the role of exogenous CD28 stimulation in regulating the production of IFN-gamma ... The enhancement of IFN-gamma production induced by direct CD28 stimulation was primarily dependent on endogenous IL-12 or CD40L/CD40 stimulation
Ding et al., J Immunol 1998 : Enhancement of costimulation by engagement of CD28 only resulted in augmentation of the capacity of the weak agonist APL to induce proliferation and IL-2/IL-3 production, but not CD40L or IL-12Rbeta2 chain expression on T cells, CD80/CD86 expression on APC, IL-12 secretion, or IFN-gamma production