◀ Back to IKBKB

CD28 — IKBKB

Text-mined interactions from Literome

Khoshnan et al., J Immunol 1999 : We demonstrate that stimulation of primary human CD4+ T cells by CD3/CD28 activates two distinct endogenous IKK complexes, a heterodimeric IKK alpha/beta and a homodimeric IKK beta complex ... We demonstrate that stimulation of primary human CD4+ T cells by CD3/CD28 activates two distinct endogenous IKK complexes, a heterodimeric IKK alpha/beta and a homodimeric IKK beta complex
Khoshnan et al., J Immunol 2000 : Taken together, these data demonstrate that CD3/CD28 induced activation of IKK beta and expression of Bcl-xL promote the survival of primary human CD4+ T lymphocytes
Khoshnan et al., J Immunol 2000 : The physical association of protein kinase C theta with a lipid raft associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28
Dienz et al., J Immunol 2003 : In contrast, replenishment of SLP-76 or PLCgamma1 expression restored CD3/CD28 induced IkappaB kinase (IKK) activity as well as NF-kappaB DNA binding and transactivation
Perchonock et al., Mol Cell Biol 2006 (Splenomegaly) : While TCR/CD28 mediated activations of phosphotyrosine induction, extracellular signal regulated kinase 1/2, Jun N-terminal protein kinase, IkappaB kinase alpha/beta , and Akt were unaltered, constitutive activation of p38 mitogen activated protein kinase and its upstream regulators MKK3/6 were observed for ALX-deficient splenocytes
Düwel et al., J Immunol 2009 : However, proteasomal inhibition impairs A20 degradation and impedes TCR/CD28 induced IKK activation