Gene interactions and pathways from curated databases and text-mining

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CD36 — TGFB1

Text-mined interactions from Literome

Yehualaeshet et al., Am J Pathol 1999 : These findings suggest that activation of L-TGF-beta1 by plasmin occurs at the cell surface of activated alveolar macrophages and requires a TSP-1/CD36 interaction
Han et al., J Biol Chem 2000 : In this study, we investigated the effect of transforming growth factor-beta1 ( TGF-beta1 ) and TGF-beta2 on the expression of CD36 in macrophages ... TGF-beta1/TGF-beta2 also inhibited CD36 mRNA expression induced by oxidized low density lipoprotein and 15-deoxyDelta ( 12,14 ) prostaglandin J ( 2 ), a peroxisome proliferator activated receptor ( PPAR)-gamma ligand, suggesting that the TGF-beta1/TGF-beta2 down-regulated CD36 expression by inactivating PPAR-gamma mediated signaling
Minami et al., Biochem Biophys Res Commun 2000 : On the other hand, transforming growth factor (TGF)-beta(1) , which plays crucial roles in vascular remodeling and the pathogenesis of atherosclerosis, has been shown to inhibit expression of class A scavenger receptors and CD36 in macrophages
Wang et al., Respir Res 2009 (Disease Models, Animal...) : Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica induced lung fibrosis in the rat ... The lentiviral vector ( Lv-shCD36 ) silenced expression of CD36 in alveolar macrophages ( AMs ) obtained from bronchoalveolar lavage fluid ( BALF ) and the activation of L-TGF-beta1 in the BALF was inhibited by Lv-shCD36 ... These results indicate that silencing expression of CD36 can result in the inhibition of L-TGF-beta1 activation in a rat silicosis model, thus further preventing the development of silica induced lung fibrosis