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CD86 — VIP
Text-mined interactions from Literome
Ganea et al., Cell Mol Biol Incl Cyto Enzymol 2003
:
In addition,
VIP/PACAP reduce the expression of costimulatory molecules ( particularly CD80 and
CD86 ) on the antigen presenting cells, and therefore reduce stimulation of antigen-specific CD4+ T cells
Fabricius et al., J Immunol 2006
:
VIP enhanced PDC expression of
CD86 , MHC II, and CCR7
Chorny et al., Ann N Y Acad Sci 2006
(Autoimmune Diseases) :
In contrast,
VIP reduces both
CD86 and CD80 expression on lipopolysaccharide (LPS) stimulated DCs, and inhibits the capacity of DCs to induce in vitro or in vivo T cell proliferation
Gonzalez-Rey et al., Curr Pharm Des 2007
:
In addition,
VIP/PACAP reduce the expression of costimulatory molecules ( particularly CD80 and
CD86 ) on the antigen presenting cells, and therefore reduce stimulation of antigen-specific CD4 ( + ) T cells
Lu et al., Int Immunopharmacol 2008
:
In the absence of LPS,
VIP , in a dose dependent manner,
up-regulated the expression of CD80,
CD86 , CD54 and CD40, but down-regulated the expression of MHC class II molecule ( Ia ( b ) )