Gene interactions and pathways from curated databases and text-mining

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CDH1 — TCF23

Text-mined interactions from Literome

Suriano et al., Oncogene 2003 : All the E-cadherin mutants reduced TCF-LEF activation to a similar extent as the wild-type protein, suggesting that the oncogenic effect of the E-cadherin mutants is unlikely to be transmitted through a beta-catenin dependent activation of the WNT pathway
Eger et al., Oncogene 2004 (Disease Progression...) : These results demonstrate that loss of E-cadherin can contribute to increased LEF/TCF-beta-catenin signalling, which in turn cooperates with autocrine TGFbeta signalling to maintain an undifferentiated mesenchymal phenotype
Gottardi et al., J Cell Biol 2004 : Beta-catenin plays essential roles in both cell-cell adhesion and Wnt signal transduction, but what precisely controls beta-catenin targeting to cadherin adhesive complexes, or T-cell factor ( TCF ) -transcriptional complexes is less well understood
Chakrabarty et al., Cancer Res 2005 (Colonic Neoplasms...) : Ca ( 2+ ) strongly induced E-cadherin expression and inhibited the expression of the nuclear transcription factor , TCF4
Blechschmidt et al., Virchows Arch 2007 (HELLP Syndrome) : Snail, a zinc-finger transcription factor represses the transcription of the cell adhesion molecule E-cadherin
Herranz et al., Mol Cell Biol 2008 : Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor
McPhee et al., Dev Dyn 2008 : Repression of E-cadherin expression by the transcription factor , Snail, is implicated in epithelial to mesenchymal transition and cancer progression