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CDKN1A — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Flørenes et al., Oncogene 1999
(Disease Progression...) :
Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor
p21WAF1/CIP1 is lost during progression of human malignant melanoma ... Instead,
IL-6 caused a marked induction of the cdk inhibitor
p21WAF1/CIP1 in three different IL-6 sensitive cell lines, two of which also showed a marked accumulation of the cdk inhibitor p27Kip1 ... In contrast,
IL-6 failed to induce p21WAF1/CIP1 transcript and did not
increase p21WAF1/CIP1 or p27kip1 proteins in any of the resistant lines ...
IL-6 dependent upregulation of
p21WAF1/CIP1 was associated with binding of both STAT3 and STAT1 to the p21WAF1/CIP1 promoter
Lavelle et al., Am J Hematol 2001
(Multiple Myeloma) :
Our results indicated that decreased
IL-6R expression was not
required for induction of
p21 ( WAF1 ) or apoptosis
Perlman et al., J Immunol 2003
(Arthritis, Rheumatoid) :
IL-6 and matrix metalloproteinase-1 are
regulated by the cyclin dependent kinase inhibitor
p21 in synovial fibroblasts
Muroya et al., Oncogene 1992
:
In contrast, basic fibroblast growth factor,
interleukin 6 and dibutyryl cAMP, which induce neuronal differentiation of PC12 cells, did not
stimulate the accumulation of
p21-GTP at any time point examined
Sun et al., Biochem Biophys Res Commun 2005
:
IL-6 induced
p21cip1 protein expression in primary mouse hepatocytes ... Finally,
IL-6 induced higher levels of
p21cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3+/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3+/- mice
Moran et al., J Surg Res 2008
(Carcinoma, Hepatocellular...) :
These data demonstrate that, while IL-6 plays a central role in hepatocyte priming and proliferation in vivo, the pronounced inhibition of proliferation observed in HCC cells occurs due to
IL-6-STAT3 dependent regulation of cdk2/cdk4 activity and
p21 ( waf1/cip1 ) expression
Tong et al., Mol Cell Biol 1998
:
Forced expression of Gfi-1B, but not of Gfi-1B deletion mutants lacking the repressor domain, blocked the
IL-6 mediated induction of
p21WAF1 and inhibited G1 arrest and differentiation ... We conclude that Gfi-1B is a direct repressor of the p21WAF1 promoter, the first such repressor identified to date, and that sustained expression of Gfi-1B blocks
IL-6 induced G1 arrest and differentiation of M1 cells perhaps because it prevents
p21WAF1 induction by IL-6