Gene interactions and pathways from curated databases and text-mining

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CDKN1A — IL6

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Flørenes et al., Oncogene 1999 (Disease Progression...) : Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma ... Instead, IL-6 caused a marked induction of the cdk inhibitor p21WAF1/CIP1 in three different IL-6 sensitive cell lines, two of which also showed a marked accumulation of the cdk inhibitor p27Kip1 ... In contrast, IL-6 failed to induce p21WAF1/CIP1 transcript and did not increase p21WAF1/CIP1 or p27kip1 proteins in any of the resistant lines ... IL-6 dependent upregulation of p21WAF1/CIP1 was associated with binding of both STAT3 and STAT1 to the p21WAF1/CIP1 promoter
Lavelle et al., Am J Hematol 2001 (Multiple Myeloma) : Our results indicated that decreased IL-6R expression was not required for induction of p21 ( WAF1 ) or apoptosis
Perlman et al., J Immunol 2003 (Arthritis, Rheumatoid) : IL-6 and matrix metalloproteinase-1 are regulated by the cyclin dependent kinase inhibitor p21 in synovial fibroblasts
Muroya et al., Oncogene 1992 : In contrast, basic fibroblast growth factor, interleukin 6 and dibutyryl cAMP, which induce neuronal differentiation of PC12 cells, did not stimulate the accumulation of p21-GTP at any time point examined
Sun et al., Biochem Biophys Res Commun 2005 : IL-6 induced p21cip1 protein expression in primary mouse hepatocytes ... Finally, IL-6 induced higher levels of p21cip1 protein expression and a slightly stronger inhibition of cell proliferation in SOCS3+/- mouse hepatocytes compared to wild-type hepatocytes, while liver regeneration was enhanced and prolonged in SOCS3+/- mice
Moran et al., J Surg Res 2008 (Carcinoma, Hepatocellular...) : These data demonstrate that, while IL-6 plays a central role in hepatocyte priming and proliferation in vivo, the pronounced inhibition of proliferation observed in HCC cells occurs due to IL-6-STAT3 dependent regulation of cdk2/cdk4 activity and p21 ( waf1/cip1 ) expression
Tong et al., Mol Cell Biol 1998 : Forced expression of Gfi-1B, but not of Gfi-1B deletion mutants lacking the repressor domain, blocked the IL-6 mediated induction of p21WAF1 and inhibited G1 arrest and differentiation ... We conclude that Gfi-1B is a direct repressor of the p21WAF1 promoter, the first such repressor identified to date, and that sustained expression of Gfi-1B blocks IL-6 induced G1 arrest and differentiation of M1 cells perhaps because it prevents p21WAF1 induction by IL-6