◀ Back to MAPK14

CDKN1A — MAPK14

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → MAPK14 (directlyIncreases, CDKN1A Activity) Kim et al., J Biol Chem 2002*
  Evidence: p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro.Peptide mapping demonstrated that both TGF-beta 1 and p38 alpha induced phosphorylation of p21 at Ser(130) in vivo, and mutation of Ser(130) to alanine rendered p21 less stable than wild-type p21.

Text-mined interactions from Literome

Blagosklonny et al., Leukemia 1999 (Leukemia, Myeloid) : In comparison, the stimulation of Raf-1 by phorbol ester ( TPA ) activates the MAPK pathway, causes MAPK dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis
Geijsen et al., Blood 1999 : Furthermore, fMLP induced p21rac activation was not inhibited by broad tyrosine kinase inhibitors or specific inhibitors of ERK, p38 mitogen activated protein kinase , Src, or phosphatidylinositol 3-kinases
Kibbe et al., Semin Perinatol 2000 (Vascular Diseases) : Instead, p42/44 mitogen activated protein kinase activation by NO results in reduced cellular proliferation and increased p21 expression, suggesting NO inhibits intimal hyperplasia through cell cycle arrest as mediated by p21 and the signaling pathway involved in p21 upregulation may be regulated by p42/44 mitogen activated protein kinase
Das et al., FEBS Lett 2000 : MAPK dependent expression of p21 ( WAF ) and p27 ( kip1 ) in PMA induced differentiation of HL60 cells
Howe et al., Nat Cell Biol 2000 (MAP Kinase Signaling System) : Interestingly, constitutively active p21 activated kinase (PAK) also allows anchorage independent MAPK signalling
Park et al., Mol Biol Cell 2000 (Carcinoma, Hepatocellular...) : MAPK signaling increased the phosphorylation of the transcription factors Ets2, C/EBPalpha, and C/EBPbeta, and rapidly increased transcription from the p21 promoter via multiple Ets- and C/EBP-elements within the enhancer region ... Eight hours after MAPK activation, loss of C/EBPbeta or Ets2 function significantly reduced MAPK stimulated transcription from the p21 promoter and abolished increased p21 protein expression ... At this time, MAPK signaling increased both p21 mRNA and p21 protein stabilities that were also demonstrated to be essential for a profound increase in p21 protein levels ... In contrast, loss of C/EBPalpha function modestly reduced MAPK stimulated transcription from the p21 promoter but strongly inhibited the ability of prolonged MAPK activation to increase protein levels of p21 ... In agreement with this hypothesis, prolonged MAPK signaling further increased p21 mRNA stability at 36 h, compared with the 8-h time point ... Our data argue that MAPK signaling increased p21 promoter activity via multiple transcription factors, which alone were insufficient for a robust prolonged increase in p21 protein levels in primary hepatocytes, and that to increase p21 protein levels also required enhanced stabilization of p21 mRNA and p21 protein
Raggatt et al., J Endocrinol 2000 : CT treatment of cells expressing the insert -ve, but not insert +ve hCTR, induced the phosphorylation of Erk1/2 MAPK , which persisted for at least 72 h. Treatment of cells expressing the insert -ve hCTR with the MAPK kinase ( MEK ) inhibitor, PD-98059, inhibited the phosphorylation of Erk1/2 and abrogated the growth inhibitory effects of salmon CT, the accumulation of cells in G2, and the associated induction of p21 ( WAF1/CIP1 )
Tadlock et al., Hepatology 2001 (Bile Duct Neoplasms...) : Inhibition of p38 MAPK , but not of p44/p42 MAPK signaling, decreased cell cycle progression and increased expression of the cyclin dependent kinase inhibitor p21 ( WAF1/CIPl )
Ranginwale et al., Exp Cell Res 2001 (MAP Kinase Signaling System) : We now directly confirm this prediction by showing that oncogenic p21 induces activating phosphorylation of JNK ( JNK-P ) and of ERK ( MAP kinase ) ( MAPK-P ), whose levels correlate with oocyte maturation
Kim et al., J Cell Physiol 2002 : Expression of dominant negative p38MAPK also blocked arsenite induced p21 ( CIP1/WAF1 ) expression
Timms et al., Oncogene 2002 (Breast Neoplasms...) : MAPK dependent induction of p21 ( Cip1 ) was also necessary for G1 phase progression, although its degradation by the proteasome was required for S phase entry
Moon et al., J Cell Physiol 2004 : Expression of dominant negative p38MAPK and SB203580, a p38MAPK specific inhibitor, blocked PDTC dependent p38MAPK, growth inhibition, and p21 expression
Moon et al., Biochem Biophys Res Commun 2004 : Transcription factor Sp1 mediates p38MAPK dependent activation of the p21WAF1 gene promoter in vascular smooth muscle cells by pyrrolidine dithiocarbamate ... This increase in p21WAF1 gene expression was due to p38MAPK dependent activation of the p21WAF1 promoter by PDTC ... In conclusion, we report the novel finding that transcription factor Sp1 that is involved in the p38MAPK mediated control of p21WAF1 regulation on VSMC in response to PDTC has now been identified
Hermanová et al., Neoplasma 2004 (Adenocarcinoma...) : The effects of HER-2/neu overexpression on mitogenic signalling and cell cycle progression were studied in breast luminal epithelial cells and mitogen activated protein kinase dependent induction of p21 ( WAF1/CIP1 ) was found to be necessary for G1 phase progression
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : The induced levels of HO-1 and p21 were significantly reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Philip et al., Cell Signal 2005 : Furthermore, we found that the p38 MAPK played an important role in GDF-8 induced inhibition of proliferation and upregulation of the cyclin kinase inhibitor p21
Nuntharatanapong et al., Am J Physiol Heart Circ Physiol 2005 : Moreover, inhibition of JNK with SP-600125 or dominant negative MKK7 inhibited only p21Cip1/Waf1 induction, whereas the p38 MAPK inhibitor SB-203580 or dominant negative MKK4 inhibited both p21Cip1/Waf1 and p53 induction
Miura et al., Atherosclerosis 2005 (Atherosclerosis...) : JTT-705 induced the upregulation of p-p21 ( waf1 ), and this effect was blocked by dominant negative Ras ( N17 ), but not by inhibitors of p38 MAPK or ERK
Nicke et al., Mol Cell 2005 (Cell Transformation, Neoplastic...) : p38 MAPK activation is essential for Ras induced p21 ( WAF1/CIP1 ) upregulation and cell cycle arrest
Yang et al., FASEB J 2006 (MAP Kinase Signaling System) : CSE mediated apoptosis was associated with an increased ERK and p38 MAPK activation , up-regulation of p21 ( Cip/WAK-1 ), and down-regulation of cyclin D1 expression
Rousseau et al., Cell Signal 2006 (MAP Kinase Signaling System) : We also show that the activation of p38alpha MAPK in response to CXCL12 requires the p21 activated protein kinases (PAK)-1 and PAK-2
Sheng et al., Gastroenterology 2006 (Colonic Neoplasms) : EGFR mediated induction of enterocyte proliferation requires MAPK dependent increase in p21 ( waf1/cip1 ) expression in intestinal epithelial cells
Devgan et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Although several of these genes are induced by p21 in a MAPK dependent manner, expression of IGF-I is induced upstream of MAPK activation
Moon et al., Biochem Biophys Res Commun 2006 : This increase in p21WAF1 gene expression was due to p38MAPK dependent activation of the p21WAF1 promoter by BITC ... In conclusion, we report that the transcription factor Sp1 involved in the p38MAPK mediated control of p21WAF1 regulation on VSMC in response to BITC has now been identified
Pivoriūnas et al., Mol Cell Biochem 2007 (Leukemia) : LY294002 potentiated expression of p21WAF1/Cip1 via a p53 independent mechanism and did not affect mitogen activated protein kinase ( MAPK ) activation
Wang et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In this study, RA is found to cause MAPK activation with sustained association of RAF to MEK or ERK, leading to a MAPK dependent accumulation of p21 ( Waf1/Cip1 ) and binding to CDK2 blocking G ( 1 ) /S transition
Pang et al., J Cell Physiol 2008 : Our study demonstrated that both the functional DRE and the phosphorylation of p38MAPK are essential for the induction of p21 and p27, resulting in the antiproliferative action of 3MC in HUVECs
Adler et al., Ann Clin Lab Sci 2008 (Cell Transformation, Neoplastic...) : We also find that in oocytes induced to mature with oncogenic ras-p21 , which induces high levels of phosphorylated JNK and MAPK , the same pattern of phosphorylation of raf occurs
Moosavi et al., Toxicol Appl Pharmacol 2008 : The occurrence of apoptosis in these cells were accompanied with caspase-8 mediated p21 cleavage and delayed activation ( 24 h ) of JNK1/2 and p38 MAPK
Zhou et al., Cancer Lett 2009 (Necrosis...) : MAPK activation induced p21 ( cip-1 ), which suppressed the levels of cyclin D1 that controls the G ( 1 ) /S cell cycle transition
Xie et al., Med Oncol 2010 (Breast Neoplasms) : These effects were blocked by the MAP kinase blocker PD98059 ( 25 µM ), indicating that MAPK plays a role in VDR and p21 upregulation
Andrade et al., Mem Inst Oswaldo Cruz 2010 : Our findings are also consistent with the notion that the VGF mediated change in p21WAF1/Cip1 expression is dependent on tyrosine kinase pathway ( s ) and is partially dependent on mitogen activated protein kinase/extracellular-signal regulated kinase 1/2
Besancenot et al., PLoS Biol 2010 : Here, we show that TPO induces cell-cycle arrest in the megakaryocytic UT7-MPL cell line by the activation of the ERK/MAPK pathway, induction of p21CIP transcription, and senescence markers through EGR1 activation
Kook et al., J Cell Physiol 2012 (MAP Kinase Signaling System) : Pharmacological inhibitor of p38 MAPK suppressed the force mediated growth inhibition as well as the decrease in p21 expression
Napione et al., Angiogenesis 2012 : These results indicate that the angiostatic action of IL-12 stimulated lymphomononuclear cells may lie in the capability to arrest endothelial cells in G1 phase through a mechanisms mainly based on the specific up-regulation of p21 ( Cip1/Waf1 ) induced by the combined activity of STAT1, PKCd and p38 MAPK
Yang et al., Phytother Res 2013 : The expression of p53 and its downstream genes p21 ( WAF1 ) and Bax were enhanced by blocking the activation of p42/p44 MAPK in response to treatment with vitexin
Hazawa et al., FEBS open bio 2012 : VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK dependent p21 induction after radiation exposure through regulation of the activity of GSK-3ß
VanRenterghem et al., J Biol Chem 1994 : In addition, preincubation of extracts with cAMP dependent protein kinase (PKA) blocks stimulation of MAPK by cyclin, p21V12ras , PKC, or pp60v-src, by at least 50 %, but stimulation by c-Mos is unaffected
Itoh et al., Proc Natl Acad Sci U S A 1993 : A protein factor for ras p21 dependent activation of mitogen activated protein ( MAP ) kinase through MAP kinase kinase ... To identify the direct target molecule of ras p21 in higher eukaryotes, we have recently developed the cell-free system in which ras p21 activates mitogen activated protein ( MAP ) kinase/extracellular signal regulated kinase ( ERK )
Liu et al., Cancer Res 1996 : Using an experimental approach involving cotransfection of a p21WAF1/CIP1 promoter-luciferase construct with a variety of plasmids expressing dominant positive or dominant negative mutant proteins involved in this signaling pathway, we provide evidence to support a role for mitogen activated protein kinase in the transcriptional activation of p21WAF1/CIP1 by growth factor stimulation
Dufourny et al., J Biol Chem 1997 (Breast Neoplasms) : The anti-proliferative effect of TPA in these cells may be accounted for, at least in part, by the MAPK dependent stimulation of the synthesis of p21 ( WAF1/CIP1 ), an inhibitor of cyclin/cyclin dependent kinase complexes
Auer et al., Biochem J 1998 : Ablation of the expression of CCAATT enhancer binding protein alpha ( C/EBPalpha ), but not of the expression of C/EBPbeta, decreased the ability of MAPK signalling to induce p21Cip-1/WAF1