Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Yohn et al., BMC urology 2011 (Carcinoma, Transitional Cell...) : Phosphatidylinositol 3'-kinase, mTOR , and glycogen synthase kinase-3ß mediated regulation of p21 in human urothelial carcinoma cells
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1, which were blocked by the inhibition of Akt, mTOR and Notch
Chiang et al., Mol Cancer Ther 2007 : Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2 overexpressing cancer cells