Gene interactions and pathways from curated databases and text-mining

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CDKN1A — NR4A1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : Activation of p21 promoter constructs by DIM-C-pPhOCH3 required the GC-rich proximal region of the promoter, and results of RNA interference studies showed that Nur77 dependent activation of the p21 promoter involved interactions with Sp1 and Sp4 but not Sp3
Hewitt et al., FASEB J 2010 (Body Weight) : Nr4a1 increased 24.5- and 14.7-fold, Cdkn1a increased 14.2- and 12.3-fold, and c-fos increased 20.9-fold and 16.2-fold after IGF1 and EGF treatments, respectively, in the Ex3aERKO mice, confirming that growth factor regulation is independent of ERa