Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Dan et al., Cancer Res 2007 (Prostatic Neoplasms) : Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha ... The experiments show that IKK alpha controls mTOR kinase activity in Akt-active, PTEN-null prostate cancer cells, with less involvement by IKK beta ... Additionally, IKKalpha is required for efficient induction of mTOR activity downstream of constitutively active Akt expression
Minhajuddin et al., J Immunol 2005 : Analysis of the NF-kappaB signaling pathway revealed that inhibition of mTOR potentiated IkappaB kinase activation resulting in a rapid and persistent phosphorylation of IkappaBalpha on Ser32 and Ser36, a requirement for IkappaBalpha degradation
Dan et al., J Immunol 2008 : Previously, we showed that activation of mTOR in PTEN-deficient cancer cells involves IkappaB kinase (IKK) alpha, a catalytic subunit of the IKK complex that controls NF-kappaB activation ... In this study, we have explored the involvement of both IKKalpha and IKKbeta in insulin- and TNF induced mTOR activation