Kaminski et al., Toxicol Lett 1998
:
Both CB1 and CB2 negatively regulate adenylate cyclase activity through a pertussis toxin sensitive GTP binding protein
Mukhopadhyay et al., Eur J Biochem 2001
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The CB1 cannabinoid receptor in N18TG2 neuroblastoma cells inhibits adenylate cyclase , and this response can be mimicked by a peptide corresponding to the juxtamembrane C-terminal domain ( CB(1)401-417 )
Bayewitch et al., FEBS Lett 1995
:
Activation of the CB2 receptor by various tricyclic cannabinoids inhibits adenylate cyclase activity and this inhibition is pertussis toxin sensitive indicating that this receptor is coupled to the Gi/G ( o ) GTP binding proteins