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CREB3 — GSK3B
Pathways - manually collected, often from reviews:
-
KEGG Prostate cancer:
GSK3B
→
ATF4/CREB1/CREB3/CREB3L1/CREB3L2/CREB3L3/CREB3L4/CREB5
(protein-protein, inhibition)
Text-mined interactions from Literome
Grimes et al., J Neurochem 2001
:
CREB DNA binding activity is
inhibited by
glycogen synthase kinase-3 beta and facilitated by lithium ... Inhibition of
GSK3 beta by another paradigm, treatment with the selective inhibitor lithium, also
increased CREB DNA binding activity ... The inhibitory
regulation of
CREB DNA binding activity by
GSK3 beta also was evident in differentiated SH-SY5Y cells, indicating that this regulatory interaction is maintained in non proliferating cells ... These results demonstrate that inhibition of
GSK3 beta by serine-9 phosphorylation or directly by lithium
increases CREB activation ... Conversely, overexpression of active
GSK3 beta to 3.5-fold the normal levels completely
blocked increases in
CREB DNA binding activity induced by epidermal growth factor, insulin-like growth factor-1, forskolin, and cyclic AMP
Mai et al., J Neurochem 2002
(Neuroblastoma) :
Therefore, increased
GSK3beta selectively
attenuates BDNF induced
CREB phosphorylation, and lithium and carbamazepine can facilitate activation of CREB
Hansen et al., Neuroreport 2004
(Neuroblastoma) :
We conclude that
GSK-3beta regulates cAMP induced CCK transcription by reducing
CREB binding to the CRE ( -80 ) element in the CCK promoter
Singh et al., International journal of biological sciences 2007
:
Suppression of
GSK-3beta by SB216763 ( 100 nM )
increases CREB phosphorylation, cyclin D1 and fibronectin levels
Xia et al., Neuropharmacology 2010
(MAP Kinase Signaling System) :
Finally, either BDNF or
GSK-3beta inhibition
prevented PCP induced suppression of cyclic-AMP response element binding protein (
CREB ) phosphorylation ... These data demonstrate that the protective effect of BDNF against PCP induced apoptosis is mediated by parallel activation of the PI-3K/Akt and ERK pathways, most likely involves inhibition of
GSK-3beta and
activation of
CREB