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CRK — IL1A

Text-mined interactions from Literome

Hashimoto et al., Eur Respir J 1999 : Inhibition of TNF-alpha- and IL-1alpha induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression, indicating that SB 203580 was effective at the transcriptional level
Matthews et al., Cytokine 1999 (Thymoma...) : Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen activated protein kinases ( MAP kinases ) in target cells
Mengshol et al., Arthritis Rheum 2000 (MAP Kinase Signaling System) : We found that IL-1 induction of MMP-13 requires p38 activity, c-Jun N-terminal kinase (JNK) activity and NF-kappaB translocation ... These studies demonstrate, for the first time, that p38 , JNK, and NF-kappaB are required for IL-1 induction of MMP-13
Kumar et al., J Cell Physiol 2001 (Bone Resorption) : In addition, IL-1 and TNF also activated p38 MAPK in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM )
McDermott et al., J Biol Chem 2002 : In the same manner, the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88, IRAK, and TRAF6, since the activation of p38 MAPK by these components was inhibited by overexpressing active Rap1AV12, while neither MKK3 nor MKK6 were affected
Ling et al., Biochem J 2004 (Inflammation) : Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or TNF-alpha in the presence of HC-gp39 resulted in a marked reduction of both p38 mitogen activated protein kinase and stress activated protein kinase/Jun N-terminal kinase phosphorylation, whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded
Wu et al., J Neurochem 2004 (Translocation, Genetic) : In accordance with these findings, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38 , and c-Jun N-terminal kinase (JNK), which was attenuated by U0126, SB202190, or SP600125, respectively
Sawai et al., Oncogene 2006 (Disease Progression...) : Alteration of ILK kinase activity controlled IL-1alpha induced p38 MAPK phosphorylation and its downstream AP-1 activation with subsequent regulation of pancreatic cancer cell adhesion and invasion ... Overexpressed ILK enhances the IL-1alpha induced p38 MAPK phosphorylation more strongly through glycogen synthase kinase 3 ( GSK-3 ) activation, and subsequently induces AP-1 activation, which promotes aggressive capabilities of pancreatic cancer cells
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine signaling (SOCS)-3 was shown to inhibit IL-1 induced transcription and activation of NFkappaB and the MAPKs JNK and p38 , but the mechanism is unknown
Fan et al., Cell Signal 2011 : Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1ß induced Lys63 linked TAK1 polyubiquitination and TAK1 mediated IKK, JNK, and p38 activation
Chen et al., Vet Res 2011 : Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression, suggesting the differential regulatory roles of p38 and JNK in IL-1ß , IL-8 and TNF-a production
Pang et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : Telmisartan did not modify IL-1ß induced ERK1/2 and p38 mitogen activated protein kinase ( MAPK ) phosphorylation or nuclear factor-?B activation but significantly decreased IL-1ß induced c-Jun N-terminal kinase (JNK) and c-Jun activation
Howard et al., Shock 2013 (Acute Lung Injury...) : Twenty-four hours after heat shock, both IRAK1 and TAK1 are again detergent soluble, which correlates with the IL-1ß dependent p38 activation