Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Avruch et al., Oncogene 2006 : Amino-acid depletion inhibits TORC1 acting predominantly downstream of the TSC complex, by interfering with the ability of Rheb to bind to mTOR
Vu et al., Clin Cancer Res 2010 (Leukemia...) : The majority of preclinical and clinical efforts to target TOR have involved using rapamycin and its analogs ( rapalogs ), which suppress TORC1 only partially and do not acutely inhibit TORC2