Gene interactions and pathways from curated databases and text-mining

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CSF2 — CUL1

Text-mined interactions from Literome

Pyatt et al., Mol Pharmacol 1996 : Support for this conclusion came from experiments demonstrating that 1 ) mutant mice strains constitutively lacking a SCF-responsive population of HPC [ White spotted ( W/WV ) and Steel ( SI/SId ) ] are unresponsive to xanthine/XO- and SCF induced enhancement of GM-CSF and 2 ) 3,4-epoxybutene, which selectively abrogates SCF synergy with GM-CSF, inhibits xanthine/XO induced enhancement
Cardier et al., Stem Cells 1997 : Moreover, GM-CSF in the presence of SCF and IL-3 potentiates the HPP-CFC formation ( i.e., an increase of 3.1-fold compared to the effect induced by SCF+IL-3 ) with strong inhibitory effects on the number and size of megakaryocyte colonies