Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Momose et al., J Antibiot (Tokyo) 2001 : Tyropeptin A inhibited the chymotrypsin-like (ChT-L) and trypsin-like ( T-L ) activities of 20S proteasome with IC50 values of 0.1 microg/ml and 1.5 microg/ml respectively, but did not inhibit the peptidylglutamyl-peptide hydrolyzing ( PGPH ) activity of 20S proteasome at a concentration of 100 microg/ml
Momose et al., Biosci Biotechnol Biochem 2005 : Among the synthesized derivatives, the most potent compound, TP-104, exhibited a 20-fold inhibitory potency enhancement for chymotrypsin-like activity of 20S proteasome compared to tyropeptin A. Additionally, TP-110 specifically inhibited the chymotrypsin-like activity, but did not inhibit the post-glutamyl-peptide hydrolyzing ( PGPH ) and the trypsin-like activities of 20S proteasome