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BMP4 — CTSH

Text-mined interactions from Literome

Lü et al., J Biol Chem 2007 : Moreover, we show that Ctsh controls the availability of mature Bmp4 protein in the embryonic lung and that inhibiting Ctsh activity leads to a marked accumulation of Bmp4 protein and disruption of branching morphogenesis ... The presence of both Ctsh and Bmp4 or Bmp4 signaling activity in other developing structures, such as the kidney, yolk sac, and choroid plexus, suggests a possible general role of Ctsh in regulating Bmp4 proteolysis in different morphogenetic events
Rojnik et al., Radiology and oncology 2011 : In order to clarify whether cathepsin H also regulates BMP-4 in humans, its impact on BMP-4 expression, processing and degradation was investigated in prostate cancer ( PC-3 ), osteosarcoma ( HOS ) and pro-monocytic ( U937 ) human cell lines