Kitamura et al., Immunity 2005
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Importantly, cathepsin S inhibitors blocked reduction of MHCII alphabeta dimer, Ii, and H2-DM in the IL-6 treated DCs Pierre et al., Cell 1998
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In immature DCs, inefficient Ii chain cleavage due to low cathepsin S activity leads to the transport of class II-Ii chain complexes to lysosomes, while in mature DCs , elevated cathepsin S activity results in efficient delivery of class II alphabeta dimers to the plasma membrane