Gene interactions and pathways from curated databases and text-mining

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CCL2 — CX3CL1

Text-mined interactions from Literome

Bjerkeli et al., Rheumatology (Oxford) 2007 (Wegener Granulomatosis) : In eight of these individuals, we also examined CX3CR1 mediated chemotaxis and adhesion in T cells and monocytes as well as the effects of CX3CL1 on monocyte chemoattractant protein (MCP) 1 levels in PBMC supernatants ... Our main findings were : ( i ) WG patients had markedly increased plasma levels of CX3CL1, with particularly high levels in those with active disease, ( ii ) These increased CX3CL1 levels were accompanied by enhanced expression of its corresponding receptor, CX3XR1, in PBMC, primarily reflecting an increased proportion of CX3CR1 ( + ) CD3 ( + ) CD4 ( + ) T cells and ( iii ) The up-regulation of CX3CR1 in PBMC from WG patients affected their functional potential as shown by CX3CL1 induced enhancement of chemotaxis, adhesion, responses as well as MCP-1 stimulation
Popovic et al., J Leukoc Biol 2008 : Upon cocultivation of human monocytes with HUVEC, the thrombin dependent induction of membrane anchored CX3CL1 in HUVEC triggered monocyte adhesion and an enhanced release of the MCP-1/CCL2 by monocytes and potentiated the monocyte transendothelial migration
Escher et al., Heart 2011 (Enterovirus Infections...) : The MCP-1 secretion was 3.1-fold higher in PBMCs from EV-positive patients compared with controls, and this elevation was further increased by CX3CL1 in EV-positive patients