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CXCL10 — IRF3

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: IRF3 → CXCL10 (gene expression, expression)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: CXCL10 — IRF3 (unknown, -) Veckman et al., Virology 2006*

Text-mined interactions from Literome

Nakaya et al., Biochem Biophys Res Commun 2001 (Newcastle Disease) : On the other hand, ISG15, ISG54 and IP-10 are induced by either IRF-3 or IFN stimulated gene factor 3 ( ISGF3 )
Taima et al., Respiration 2006 : Overexpression of RIG-I or IRF-3 potentiated the poly-IC induced upregulation of IP-10 ... IP-10 may contribute to antiviral activity through the activation of Th-1-type immunity, and RIG-I and IRF-3 may be involved in this reaction
Qian et al., Blood 2007 : We show that the increased IRF-3 and IFN-beta induced STAT1 activation are responsible for the autocrine IFN-beta dependent preferential production of IP-10 by regulatory DCs
Selvarajoo et al., PloS one 2008 : To verify SFR, we treated MyD88-deficient macrophages with LPS and observed enhancement of TRAM dependent pathway based on increased IRF3 phosphorylation and induction of Cxcl10 and Ifit2