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CXCL10 — TLR9
Text-mined interactions from Literome
Wuest et al., J Neuroimmunol 2006
(Keratitis, Herpetic) :
Since HSV-1 nucleic acid is recognized by pattern receptors including Toll-like receptor (TLR) 9, we tested the hypothesis that
TLR9 is
necessary for the early augmentation of
CXCL10 following HSV-1 infection ... This is the first report that shows enhanced
CXCL10 expression following neurotropic viral replication
requires both intact
TLR 9 and type I interferon signaling pathways
Qian et al., Blood 2007
:
Blockade of IFN-alpha/beta
inhibits IP-10 production by
TLR agonist activated regulatory DCs
Wang et al., Blood 2008
:
We and others have reported that
Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment
enhances IL-8 (
CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009
:
In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of
CXCL8 , CCL2 and LL-37 in keratinocytes
Mortaz et al., Eur Respir J 2010
(Pneumonia...) :
TLR9 mediates cigarette smoke induced release of
CXCL8 and this may contribute to the accumulation of neutrophils and inflammation within the airways of smokers
Kwissa et al., Blood 2012
:
Furthermore, all
TLR-Ls induced rapid ( 3-8 hours ) expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L mobilized the CD14 ( + ) CD16 ( + ) and CD14 ( dim ) CD16 ( ++ ) monocytes, and only TLR7/8-L and TLR9-L
induced activation of myeloid dendritic cells ( mDCs ) and plasmacytoid DCs ( pDCs ), production of
IP-10 and type-I IFN, and expression of type-I IFN related and chemokine genes in the blood
Abe et al., J Virol 2012
:
In this study, we examined the
role of the
Toll-like receptor ( TLR ) pathway on
IP-10 production in cells replicating HCV
Sharma et al., J Leukoc Biol 2013
:
Our findings reveal a previously unrecognized role for S1P in regulating
TLR induced
CXCL8 secretion from human T cells