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CRKL — CXCL12

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CBL-CRKL → CXCL12 (increases) Chernock et al., Blood 2001
  Evidence: In addition, SDF-1alpha stimulation enhanced the association of cbl with PI-3 kinase, Crk-L, and 14-3-3beta proteins.
• OpenBEL Selventa BEL large corpus: CRKL → CXCL12 (increases) Wang et al., Blood 2000
  Evidence: We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation.

Text-mined interactions from Literome

Chernock et al., Blood 2001 : In addition, SDF-1alpha stimulation enhanced the association of cbl with PI-3 kinase, Crk-L , and 14-3-3beta proteins
Arai et al., Cell Signal 2006 : SDF-1 stimulation induced tyrosine phosphorylation of CrkL, which was inhibited by the Src family kinase inhibitor PP1 or by dominant negative mutants of Lyn, thus indicating that Lyn mediated SDF-1 induced phosphorylation of CrkL