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CYP19A1 — IL6
Text-mined interactions from Literome
Singh et al., Endocr Relat Cancer 1999
(Breast Neoplasms) :
PGE2, TNFalpha and
IL-6 plus its soluble receptor (IL-6sR) all
increased aromatase activity in these cells ... The ability of PGE2 to stimulate
aromatase activity in fibroblasts derived from ` normal ' breast tissue was
potentiated by
IL-6sR suggesting that PGE2 may act via induction of IL-6
Parish et al., J Steroid Biochem Mol Biol 2001
:
In this study, a 16 amino acid peptide, AROHIB, has been used in an attempt to block the ability of
IL-6 plus IL-6sR to
stimulate aromatase activity in stromal fibroblasts ... Subsequently, a series of 10 amino acid peptides, DP1-DP4, were designed, synthesised and tested for their ability to resist proteolytic degradation and to inhibit IL-6 plus
IL-6sR stimulated
aromatase activity
Purohit et al., Breast Cancer Res 2002
(Breast Neoplasms) :
The activities of the
aromatase , estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all
increased by
IL-6 and TNF-alpha
Chiu et al., Med Hypotheses 2002
:
The
IL-6 induced
aromatase activity results in increased serum estradiol level
Purohit et al., Br J Cancer 2003
:
Interleukin 6 (IL-6) and its soluble receptor ( IL-6sR ) can markedly
stimulate aromatase activity in cultured fibroblasts derived from normal or malignant breast tissues ... In this study, we have used Sant 7 to examine its ability to inhibit
IL-6+IL-6 soluble receptor (IL-6sR)
stimulated aromatase activity in breast tissue derived fibroblasts ... As previously observed,
IL-6+IL-6sR markedly
stimulated aromatase activity ( 7.7-20.8-fold ) in fibroblasts derived from reduction mammoplasty tissue, tissue proximal to tumours and breast tumours ... Sant 7 inhibited basal aromatase activity in some fibroblasts by 25-30 % that had a high basal activity, but almost completely blocked the ability of
IL-6+IL-6sR to
stimulate aromatase activity ... The IC ( 50 ) for the inhibition of
IL-6+IL-6sR stimulated
aromatase activity by Sant 7 was 60 ng ml(-1)
Deura et al., Fertil Steril 2005
(Endometriosis...) :
To examine the
effect of
interleukin-6 (IL-6) on estrogen production and
aromatase activity using a human granulosa tumor cell line ( KGN cells ) ... In addition, pretreatment with U0126 restored the
IL-6 induced suppression of
aromatase activity
Velasco et al., Mol Hum Reprod 2006
(Endometriosis) :
The aims of this study were, on the one hand, to determine the presence of aromatase in eutopic and ectopic endometrium, healthy peritoneum, myometrium and leiomyomas from patients with ( n = 61 ) and without endometriosis ( n = 12 ) and, on the other hand, to determine the
effect of peritoneal fluid ( PF ),
interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFalpha) on
aromatase activity from endometriotic stromal cells and subcutaneous adipocytes
Cutolo et al., Ann N Y Acad Sci 2006
(Autoimmune Diseases) :
Abnormal
regulation of
aromatase activity ( i.e., increased activity ) by inflammatory cytokine production ( i.e., TNF-alpha, IL-1, and
IL-6 ) may partially explain the abnormalities of peripheral estrogen synthesis in RA ( i.e., increased availability of 17-beta estradiol and possible metabolites in synovial fluids ) and in systemic lupus erythematosus, as well as the altered serum sex-hormone levels and ratio ( i.e., decreased androgens and DHEAS )
Morales-Montor et al., Curr Top Med Chem 2008
(Cysticercosis) :
Briefly, estrogens favour and androgens hinder the reproduction of cysticerci by at least two main mechanisms : 1 ) through estradiol tilting the TH2/TH1 immune system balance towards parasite-permissive TH2 response, which is
IL-6 dependent mediating
P450-aromatase over expression, shunting testosterone towards estradiol and thus creating a positive feed-back loop which progressively favours TH2 response, blocking in turns TH1 and furthers parasite growth ; and 2 ) estrogens and androgens acting directly upon the cysticercus reproductive system, favoring or hindering, respectively, its asexual reproduction
Yasuda et al., Biol Reprod 1990
:
Inhibitory
effects of
interleukin-1 on follicle stimulating hormone induction of
aromatase activity, progesterone secretion, and functional luteinizing hormone receptors in cultures of porcine granulosa cells
Macdiarmid et al., Mol Cell Endocrinol 1994
(Breast Neoplasms...) :
IL-1 and
IL-6 also
stimulated fibroblast
aromatase activity, but no marked synergism between TNF alpha and IL-1 or IL-6 was detected
Noble et al., J Clin Endocrinol Metab 1997
(Endometriosis...) :
The
effects of interleukin-1 beta (IL-1 beta), IL-2,
IL-6 , IL-11, oncostatin M, IL-15, tumor necrosis factor-alpha, PGE2, estradiol, R5020, dexamethasone, and dibutyryl cAMP ( Bt2cAMP ) on
aromatase activity in endometriosis derived stromal cells were assessed