Gene interactions and pathways from curated databases and text-mining

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CASP6 — DES

Text-mined interactions from Literome

Qi et al., Acta Pharmacol Sin 2002 (Glioma) : To study desipramine (Des) induced apoptosis and regulation of caspase 3 gene expression and [Ca2+ ] i homeostasis in rat glioma C6 cells
Salleh et al., Toxicology 2003 : DES induced the expression of 12 genes ( bad, bax, bcl-x, caspase-1, p53, cyclin D3, GADD45, p21, p15, p27, p57 and Skp1 ) and down-regulated the expression of eight genes ( bcl-2, caspase-2 , caspase-7, caspase-8, E124, iNOS, mdm2 and NFkappab1 ) at twofold or greater levels
Huang et al., J Agric Food Chem 2011 : However, caspase-6 caused increasing degradation of desmin with extended incubation time and produced three degradation fragments ( 45, 29, and 27 kDa ) of which only the 45 kDa fragment has been reported in aged beef