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DPP4 — HNF1A

Text-mined interactions from Literome

Ahrén et al., Eur J Pharmacol 2005 (Body Weight) : We conclude that DPP-4 inhibition improves islet function and increases beta cell secretory responses on a long-term basis and that this is dependent on intact expression of HNF-1alpha
Gu et al., Biochem Biophys Res Commun 2006 (Diabetes Mellitus, Type 2) : Both wild HNF-1alpha and wild HNF-1beta significantly transactivated DPP-IV promoter, but mutant HNF-1alpha and mutant HNF-1beta exhibited low transactivation activity ... These results suggest that both wild HNF-1alpha and wild HNF-1beta have a stimulatory effect on DPP-IV gene expression, but that mutant HNF-1alpha and mutant HNF-1beta attenuate the stimulatory effect
Benoit et al., Am J Physiol Gastrointest Liver Physiol 2010 : HNF-1alpha was also sufficient to induce the expression of cadherins and dipeptidylpeptidase , whereas in combination with Cdx2 it allowed the expression of the late differentiation marker sucrase-isomaltase