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CCNA2 — E2F1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: Complex of CCNA1-CCNA2-CDK2 → E2F1/E2F2/E2F3 (protein-protein, inhibition)
• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → Cyclin A (CCNA2) (transcription, activates) Schulze et al., Proc Natl Acad Sci U S A 1995*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CCNA2 — E2F1 Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
• IRef Bind_translation Interaction: CCNA2 — E2F1 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*
• IRef Bind_translation Interaction: CCNA2 — E2F1 (x-ray crystallography) Brown et al., Nat Cell Biol 1999*
• IRef Biogrid Interaction: CCNA2 — E2F1 (physical association, affinity chromatography technology) Schulman et al., Proc Natl Acad Sci U S A 1998*
• IRef Biogrid Interaction: CCNA2 — E2F1 (physical association, affinity chromatography technology) Xu et al., Mol Cell Biol 1994*
• IRef Biogrid Interaction: CCNA2 — E2F1 (direct interaction, pull down) Xu et al., Mol Cell Biol 1994*
• MIPS CORUM E2F1-p107-cyclinA complex: E2F1-p107-cyclinA complex complex (CCNA2-E2F1-RBL1) Shirodkar et al., Cell 1992*
• IRef Corum Interaction: Complex of RBL1-CCNA2-CCNA2-E2F1-E2F1-RBL1 (association, electrophoretic mobility supershift assay) Shirodkar et al., Cell 1992*
• IRef Hprd Interaction: CCNA2 — E2F1 (in vitro) Lowe et al., Biochemistry 2002*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Dynlacht et al., Mol Cell Biol 1997
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Xu et al., Mol Cell Biol 1994*
• IRef Innatedb Interaction: CCNA2 — E2F1 (unknown, -) Cartier et al., J Biol Chem 2011

Text-mined interactions from Literome

Lukas et al., Nature 1999 : These results implicate an E2F dependent , cyclin A/Cdk2 mediated phosphorylation of Cdh1 in the timely accumulation of cyclin B1 and the coordination of cell-cycle progression during the post-restriction point period
Park et al., Carcinogenesis 2001 (Prostatic Neoplasms) : Accompanying this is a reduction in the E2F-1 regulated expression of cell cycle genes such as c-myc, cyclin D1, cyclin A and cyclin B1