◀ Back to CCNA2
CCNA2 — E2F1
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
Complex of CCNA1-CCNA2-CDK2
→
E2F1/E2F2/E2F3
(protein-protein, inhibition)
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
Cyclin A (CCNA2)
(transcription, activates)
Schulze et al., Proc Natl Acad Sci U S A 1995*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK2/Cyclin A complex (CDK2-CCNA2)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, activates)
Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CCNA2
—
E2F1
Brown et al., Nat Cell Biol 1999*, Lowe et al., Biochemistry 2002*
-
IRef Bind_translation Interaction:
CCNA2
—
E2F1
(x-ray crystallography)
Brown et al., Nat Cell Biol 1999*
-
IRef Bind_translation Interaction:
CCNA2
—
E2F1
(x-ray crystallography)
Brown et al., Nat Cell Biol 1999*
-
IRef Biogrid Interaction:
CCNA2
—
E2F1
(physical association, affinity chromatography technology)
Schulman et al., Proc Natl Acad Sci U S A 1998*
-
IRef Biogrid Interaction:
CCNA2
—
E2F1
(physical association, affinity chromatography technology)
Xu et al., Mol Cell Biol 1994*
-
IRef Biogrid Interaction:
CCNA2
—
E2F1
(direct interaction, pull down)
Xu et al., Mol Cell Biol 1994*
-
MIPS CORUM E2F1-p107-cyclinA complex:
E2F1-p107-cyclinA complex complex (CCNA2-E2F1-RBL1)
Shirodkar et al., Cell 1992*
-
IRef Corum Interaction:
Complex of RBL1-CCNA2-CCNA2-E2F1-E2F1-RBL1
(association, electrophoretic mobility supershift assay)
Shirodkar et al., Cell 1992*
-
IRef Hprd Interaction:
CCNA2
—
E2F1
(in vitro)
Lowe et al., Biochemistry 2002*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Dynlacht et al., Mol Cell Biol 1997
-
IRef Hprd Interaction:
Complex of 33 proteins
(in vivo)
Xu et al., Mol Cell Biol 1994*
-
IRef Innatedb Interaction:
CCNA2
—
E2F1
(unknown, -)
Cartier et al., J Biol Chem 2011
Text-mined interactions from Literome
Lukas et al., Nature 1999
:
These results implicate an
E2F dependent ,
cyclin A/Cdk2 mediated phosphorylation of Cdh1 in the timely accumulation of cyclin B1 and the coordination of cell-cycle progression during the post-restriction point period
Park et al., Carcinogenesis 2001
(Prostatic Neoplasms) :
Accompanying this is a reduction in the
E2F-1 regulated expression of cell cycle genes such as c-myc, cyclin D1,
cyclin A and cyclin B1