Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Real et al., PloS one 2011 : The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1 's ability to bind DNA and to regulate gene transcription, demonstrating that a gene induction expression program is required in this process ... The effect of E2F1 on the activation of mTORC1 does not depend on Akt ... Immunolocalization studies demonstrate that E2F1 induces the translocation of mTORC1 to the late endosome vesicles, in a mechanism dependent of leucine
Bhattacharya et al., Cancer Biol Ther 2012 (Stomach Neoplasms) : Here, we tested the hypothesis that the dual PI3K/mTOR inhibitor, PI103, could synergize with the chemotherapeutic agent, 5-fluorouracil ( 5-FU ) by inhibiting E2F1 , thymidylate synthase ( TS ) and enhancing DNA damage