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AKT1 — E2F2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gille et al., J Biol Chem 1999
:
Activated PI 3-kinase
induces cyclin D(1) transcription and
E2F activity, at least in part mediated by the serine/threonine kinase
Akt/PKB , and to a lesser extent the Rho family GTPase Rac ... Activated PI 3-kinase
induces cyclin D(1) transcription and
E2F activity, at least in part mediated by the serine/threonine kinase
Akt/PKB , and to a lesser extent the Rho family GTPase Rac
Chaussepied et al., Mol Cell 2004
:
Transcriptional
regulation of
AKT activation by
E2F ... We identify the adaptor protein Grb2 associated binder 2 (Gab2) as a direct E2F target gene and an essential effector of
E2F dependent
AKT activation
Yin et al., Prostate 2009
(Prostatic Neoplasms) :
In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and
E2F and by
activation of
AKT
van Duijn et al., Prostate 2010
(Prostatic Neoplasms) :
Specific inhibition of
Akt signaling by siRNA
resulted in downregulation of both
E2F2 and Cdc25a mRNA expression and upregulation of the FOXO target cyclin G2, similar to the effect observed by PTEN induction
Dar et al., J Biol Chem 2011
(Melanoma...) :
The proliferative capacity of melanoma cells was suppressed by miR-205 and mediated by
E2F regulated
AKT phosphorylation
Brennan et al., Immunity 1997
:
The expression of an active
PKB is
sufficient to induce
E2F activity