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EGF — TGFB2
Text-mined interactions from Literome
Asher et al., J Neurosci 2000
(Brain Injuries) :
The amount detected was
increased by
transforming growth factor beta and to a greater extent by
epidermal growth factor and was decreased by platelet derived growth factor and, to a lesser extent, by interferon gamma
Yamasaki et al., J Invest Dermatol 2003
:
The epidermal growth factor dependent induction of p3TP-lux luciferase activity was disrupted by transfection of the dominant negative form of transforming growth factor beta type I receptor adenovirus vector ( AxdnALK5 ), which suggests that
epidermal growth factor induced
transforming growth factor beta acts in an autocrine manner in keratinocytes
Opperman et al., Dev Dyn 2006
:
In summary,
Tgf-beta2 stimulated Erk1/2 phosphorylation and
induced Egf and Erk1/2 expression, associated with suture closure after 72 hr. Blocking Erk1/2 activity with PD inhibited these effects but increased Smad2/3 expression
Song et al., J Biol Chem 2006
(Prostatic Neoplasms) :
Novel permissive
role of
epidermal growth factor in
transforming growth factor beta ( TGF-beta ) signaling and growth suppression
Danielpour et al., J Cell Physiol 1991
:
The interactive
effects of
EGF , RA, and Dex on the production of TGF-beta 1 and
TGF-beta 2 , which were studied on NRK-49F cells, demonstrate that EGF blocks the induction of TGF-beta 2 mRNA and peptide by RA, while Dex inhibits the induction of TGF-beta 1 mRNA and peptide by EGF
Rawlins et al., Experimental biology and medicine (Maywood, N.J.) 2008
:
Blocking Egf activity after Tgf-beta 2 treatment rescued sutures from Tgf-beta 2-induced obliteration, indicating that
Tgf-beta 2 required
Egf activity to induce suture obliteration
Liang et al., Arch Oral Biol 1990
:
Thus
epidermal growth factor stimulates DNA synthesis and both
transforming growth factor-beta and epidermal growth factor inhibit ALPase activity of clonal rat pulp cells, suggesting that both factors may act as regulators of biological function, including cell differentiation, in pulp cells
Matrisian et al., Mol Cell Biol 1986
:
However,
transforming growth factor beta could
block the
EGF induction of transin RNA
Nugent et al., Cancer Res 1989
(Cell Transformation, Neoplastic) :
Growth stimulation, altered
regulation of
epidermal growth factor receptors, and autocrine transformation of spontaneously transformed normal rat kidney cells by
transforming growth factor beta
Russell et al., Proc Natl Acad Sci U S A 1988
(Cicatrix...) :
Whereas
transforming growth factor beta reduced growth stimulation by epidermal growth factor in cells from normal adult skin or scars, it
enhanced the activity of
epidermal growth factor in cells from keloids
Shiota et al., Biochem Int 1986
:
Distinct
effects of
transforming growth factor-beta on
EGF receptors and EGF induced DNA synthesis in primary cultured rat hepatocytes
Brinckerhoff et al., Arthritis Rheum 1983
:
Morphologic and mitogenic responses of rabbit synovial fibroblasts to
transforming growth factor beta require transforming growth factor alpha or
epidermal growth factor
Hayward et al., In Vitro Cell Dev Biol Anim 1995
(Aneuploidy) :
In serum-free culture in plastic dishes
epidermal growth factor (EGF) , transforming growth factor (TGF)-alpha, fibroblast growth factor (FGF) 1 ( aFGF ), and FGF 7 ( KGF )
induced increased proliferation in these cells whereas FGF 2 ( bFGF ), TGF-beta 1, and
TGF-beta 2 inhibited proliferative activity
Schluns et al., Int Immunol 1995
:
In vitro,
epidermal growth factor (EGF)
increases transcript levels of TGF-beta 1, TGF-beta 3 and T beta RII, suggesting that EGF may modulate TGF-beta responses in TEC ; however,
TGF-beta 2 and T beta RI transcript levels were not affected