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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kim et al., Proc Natl Acad Sci U S A 2008 : Moreover, pharmacological inhibition of Src and EGFR blocked Alp- and Car stimulated EGFR transactivation
Poppleton et al., Arch Biochem Biophys 1999 : EGFR-13, but not EGFR-14 , increased autophosphorylation ( by twofold ) of the full-length and two truncated forms ( Delta1022-1186 and a constitutively active receptor kinase domain ) of the EGFR ... Increased receptor autophosphorylation in the presence of EGFR-13 can not solely be attributed to an increase in tyrosine kinase activity because EGFR-14 and polylysine increased tyrosine kinase activity of EGFRDelta1022-1186 and full-length EGFR , respectively, to the same extent as EGFR-13 without any effects on receptor autophosphorylation
Mukhopadhyay et al., Oncol Rep 1995 : RNase protection and nuclear run-off assays established that increases in EGFR expression in retinoic acid treated cells were not the result of increased promoter activity of EGFR gene, but were more likely the result of a posttranscriptional mechanism
Zhi et al., IUBMB Life 2012 (Adenocarcinoma, Mucinous...) : EGFR expression can be decreased by suppressing CD73 with an inhibitor or small shRNA, and this effect was reversed by adenosine and NECA ( adenosine A2 receptor agonist ), which suggested that adenosine is involved in EGFR expression regulated by CD73 ( P < 0.01 )
Zuo et al., Breast Cancer Res 2010 (Breast Neoplasms...) : To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be blocked by EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )
Qiu et al., Oncol Rep 2006 (MAP Kinase Signaling System...) : Furthermore, we observed that paclitaxel, ceramide, or combo induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126
Bandyopadhyay et al., J Biol Chem 1998 : Anti-EGFR mAb induced physical interaction between EGFR and DNA-PK or Ku70/80 was dependent on the presence of EGFR, but not on the levels of EGFR ... Our findings demonstrate the existence of a novel cellular pathway in mammalian cells that involves physical interactions between EGFR and DNA-PK or Ku70/80 in response to inhibition of EGFR signaling
Kagiyama et al., Circulation 2002 (Hypertension...) : In VSMCs, EGFR-AS ( 2.5 micromol/L ) reduced EGFR expression and inhibited the Ang II-induced phosphorylation of ERK
Ahsan et al., Cancer Res 2010 (Head and Neck Neoplasms) : Pretreatment with EGF enhanced cisplatin induced EGFR degradation and cytotoxicity, whereas erlotinib pretreatment blocked EGFR phosphorylation, degradation, and cisplatin induced cytotoxicity
Reinehr et al., FASEB J 2003 : Inhibition of EGFR tyrosine kinase activity prevented CD95 tyrosine phosphorylation and DISC formation but not hyperosmolarity induced EGFR phosphorylation and EGFR association with CD95 ... Stimulation of EGFR by EGF induced EGFR phosphorylation but no association with CD95 or CD95 phosphorylation
Shen et al., Mol Biol Cell 2007 : The interaction of ACK1 with EGFR was dependent on the kinase activity or tyrosine phosphorylation of EGFR
Servidei et al., Int J Cancer 2012 (Ependymoma) : EGFR inhibitors ( gefitinib and AEE788 ) reduced clonogenicity, proliferation and survival of ependymoma-SC lines dose-dependently, and blocked EGF induced activation of EGFR , Akt and extracellular signal regulated kinase 1/2
Adachi et al., Oncol Rep 2010 (Pancreatic Neoplasms) : These results strongly suggest that EGFR phosphorylation at Ser1046/7 via activation of p38 MAPK induced by HSP90 inhibitors plays a pivotal role in EGFR desensitization in human pancreatic cancer cells
Cathomas et al., Clin Cancer Res 2012 (Neoplasm Metastasis...) : A potential correlation between EGFR overexpression, persistent expression of PTEN, and EGFR inhibition should be investigated further
Kassel et al., J Pharmacol Exp Ther 2007 : AG-1478 and GM6001 also inhibited the LPA induced decrease in EGFR binding but only by 50 %, suggesting only partial involvement of EGFR transactivation in the decrease in EGFR binding
Annunziata et al., Clin Cancer Res 2010 (Cystadenocarcinoma, Serous...) : Proteomic analysis of paired biopsies detected both phosphorylated-EGFR and phosphorylated-VEGF receptor-2 in ovarian tumor tissue, but only phosphorylated-EGFR was measurably inhibited by vandetanib
Edmonds et al., Cancer Biol Ther 2012 (Head and Neck Neoplasms...) : We found that BPD mediated PDT stimulated EGFR tyrosine phosphorylation and nuclear translocation, and that EGFR inhibition by erlotinib resulted in reduction of PDT mediated EGFR activation and nuclear translocation
Boonanantanasarn et al., Infect Immun 2012 (Mouth Neoplasms) : Inhibitors of H ( 2 ) O ( 2 ) ( catalase ) and EGFR ( gefitinib ) significantly blocked E. faecalis induced EGFR activation and cell proliferation
Noguchi et al., Gastroenterology 1999 : HRG-alpha activated tyrosine phosphorylation of epidermal growth factor receptor (EGFR) , erbB2, and erbB3 and induced not only erbB3/erbB2 but also erbB3/EGFR and erbB2/EGFR heterodimer formation in MKN-28 cancer cells
Wu et al., J Biol Chem 2002 : These data demonstrate that Src dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and Zn2+ induced Ras activation
Adachi et al., Carcinogenesis 2009 (Colonic Neoplasms) : Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG induced downregulation of EGFR in colon cancer cells
Jiang et al., Cell stem cell 2011 (MAP Kinase Signaling System) : Here we show that in response to damage or stress in the intestinal ( midgut ) epithelium of adult Drosophila, multiple EGFR ligands and rhomboids ( intramembrane proteases that activate some EGFR ligands ) are induced , leading to the activation of EGFR signaling in intestinal stem cells ( ISCs )
Offterdinger et al., Traffic 2008 : This enhanced EGFR signaling was rather caused by erbB2 mediated retention of phosphorylated EGFR at the plasma membrane ( PM ), thereby preventing EGFR dephosphorylation and signal termination by endomembrane bound protein tyrosine phosphatases (PTPs)
Friedmann et al., Mol Cancer Ther 2006 (Neoplasms) : In this study, we specifically investigated the effect of EGFR inhibition by gefitinib on functional activity of DNA-PK in cancer cell lines and the interaction between EGFR and DNA-PK
García et al., Clin Cancer Res 2008 (Carcinoma, Non-Small-Cell Lung...) : A high correlation between anti-EGF antibody titers, EGFR phosphorylation inhibition, and EGF/EGFR binding inhibition was found
Han et al., PloS one 2011 (Carcinoma, Non-Small-Cell Lung...) : Interestingly, EGFR-TKIs can still induce cell autophagy even after EGFR expression was reduced by EGFR specific siRNAs
Abhold et al., PloS one 2012 (Carcinoma, Squamous Cell...) : Activation of EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 ) resulted in the induction of CD44, BMI-1, Oct-4, NANOG, CXCR4, and SDF-1
Dong et al., Am J Pathol 2013 (Carcinoma, Non-Small-Cell Lung...) : EGFR inhibitor blocked Derlin-1 mediated up-regulation of EGFR and ERK phosphorylation
Katakowski et al., Cancer Sci 2009 (Brain Neoplasms...) : hADAM17 up-regulated EGFR and AKT phosphorylation, and increased proliferation and cell invasion were significantly dependent upon EGFR activity
Rego et al., Br J Cancer 2010 (Adenocarcinoma...) : Phospho-EGFR expression was detected in 157 of 388 ( 40 % ) tumours, whereas EGFR was found in 214 of 361 ( 59 % )
Contessa et al., Breast Cancer Res Treat 2006 (Breast Neoplasms) : In this study the effects of EGFR-CD533 and an analogous truncation mutant of ErbB2 ( ErbB2-CD572 ) on ErbB receptor family dimerization and signaling are further investigated
Ciardiello et al., Clin Cancer Res 2004 (Adenocarcinoma...) : EGFR inhibitors such as C225 ( cetuximab ), a chimeric human-mouse anti-EGFR monoclonal antibody, and ZD1839 ( gefitinib ), a small molecule EGFR-selective tyrosine kinase inhibitor , are in advanced clinical development
Schmelz et al., Mech Ageing Dev 2004 (Colonic Neoplasms) : To test this hypothesis, we examined the expression of EGFR related protein (ERRP) , a recently identified negative regulator of EGFR , in the colonic mucosa during aging and following administration of the colonic carcinogen dimethylhydrazine ( DMH ) that resulted in the formation of aberrant crypt foci ( ACF ), which are considered to be precursor of adenoma and carcinoma
Vrailas-Mortimer et al., Dev Biol 2007 (MAP Kinase Signaling System) : We also find that Msk overexpression increases Egfr protein levels, and that msk gene function is required for proper Egfr expression in both developing wings and eyes
Richards et al., Cancer 2010 (Neuroblastoma) : Whereas EGFR inhibition with erlotinib and pan-ERBB inhibition with CI-1033 inhibited EGF induced phosphorylation of EGFR , AKT, and ERK1/2, only CI-1033 induced growth inhibition and dose dependent apoptosis in vitro
Bai et al., Life Sci 2010 (Carcinoma, Hepatocellular...) : The phosphorylation of EGFR and Akt were elevated in EP1 agonist treated cells, and both EGFR and PI3K inhibitors suppressed the upregulation of survivin induced by PGE ( 2 ) or EP1 agonist
Moroni et al., J Biol Chem 1992 (Carcinoma, Squamous Cell...) : EGF-R antisense RNA blocks expression of the epidermal growth factor receptor and suppresses the transforming phenotype of a human carcinoma cell line
Pangburn et al., Cancer prevention research (Philadelphia, Pa.) 2010 : We previously reported that metabolites of the nonsteroidal anti-inflammatory drug sulindac downregulate the expression of EGFR and inhibit basal and EGF induced EGFR signaling through extracellular signal regulated kinase 1/2
Rafiq et al., Circ Res 2008 : Cat.G induced a rapid and transient increase in EGFR tyrosine phosphorylation, and inhibition of EGFR kinase activity, either with AG1478 or by expression of kinase inactive EGFR mutants ( EGFR-CD533 ), markedly attenuated EGFR downstream signaling and myocyte anoikis induced by Cat.G
Daniele et al., Traffic 2008 : We provide evidence that ARAP1 controls the late steps of the endocytic trafficking of the EGF-R, with ARAP1 knockdown leading to EGF-R accumulation in a sorting/late endosomal compartment and to the inhibition of EGF-R degradation that is accompanied by prolonged signalling
Li et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : In addition, the enhanced phosphorylation of EGF-R in VSMC from SHR compared with WKY was also attenuated by inhibitors of AT(1), ET ( A ), ET ( B ), and EGF-R but not by inhibitors of platelet derived growth factor receptor or insulin-like growth factor receptor
Na et al., PloS one 2012 (Pancreatic Neoplasms) : Interestingly, we also found that YM155 downregulated the epidermal growth factor receptor (EGFR) in various cancer cell lines and induced the EGFR phosphorylation and ubiquitination of EGFR in PANC-1 cells
Chen et al., J Biol Chem 2001 (Cell Transformation, Neoplastic) : Anti-EGFR, anti-heparin binding EGF, and BB-94 each blocked TPA induced EGFR phosphorylation, but only anti-EGFR could block EGF induced EGFR phosphorylation
Paliga et al., Br J Cancer 2012 (Anus Neoplasms...) : EGFR and K-ras gene mutation status in squamous cell anal carcinoma : a role for concurrent radiation and EGFR inhibitors ?
Yoon et al., Cancer Res 2006 (Breast Neoplasms...) : ErbB2, a binding partner of epidermal growth factor receptor (EGFR), and EGFR modulated Ras activity, and integrin alpha(6)beta ( 4 ) regulated phospho-EGFR level without affecting EGFR expression
Donepudi et al., Cell Signal 2008 : Dual overexpression of c-Src and EGFR correlates with a Src dependent increase in activation of EGFR, and synergism between these two tyrosine kinases increases the mitogenic activity of EGFR
Walker et al., Exp Cell Res 2007 : We have confirmed the role of EGFR signalling in the G2/M phase of the cell cycle using a human tumor cell line which overexpresses the EGFR and is dependent on EGFR signalling for growth
Dittmann et al., Molecular cancer 2008 : Inhibition of EGFR by the antibody Erbitux resulted in a strong accumulation of caveolin/EGFR complexes within the cytoplasm, which could not be further increased by irradiation
Stoscheck et al., J Invest Dermatol 1992 (Hypertrophy) : This early increase in the levels of EGF-R was followed by a sharp decline in EGF-R and subsequent decline in epidermal thickness ( hypertrophy ), total protein, and DNA levels
Koese et al., Oncogene 2013 : Protein kinase Ca ( PKCa ) can phosphorylate the epidermal growth factor receptor (EGFR) at threonine 654 ( T654 ) to inhibit EGFR tyrosine phosphorylation ( pY-EGFR ) and the associated activation of downstream effectors
Zhu et al., Cancer Lett 2010 (Astrocytoma...) : The EGFR-PUMA interaction is independent of EGFR activation and is sustained under EGFR inhibition
Kusaka et al., Scand J Gastroenterol 2012 (Barrett Esophagus...) : Both EGFR phosphorylation and CDX2 induction were significantly diminished by AG 1478 and EGFR-siRNA
Wang et al., J Biol Chem 2003 : Stimulation of EGFR and mitogen activated protein kinase signaling by GM3 depletion involves the phosphorylation of EGFR at tyrosine residues 845, 1068, and 1148 but not 1086 or 1173
Kim et al., Lung Cancer 2012 (Adenocarcinoma...) : The aim of this study is to examine the EGFR mutational status by both direct DNA sequencing and peptide nucleic acid ( PNA ) -mediated real-time PCR clamping and to evaluate the correlation between the EGFR mutational status and the clinical response to EGFR-tyrosine kinase inhibitors
Sundberg et al., Eur J Nucl Med Mol Imaging 2003 (Astrocytoma...) : The EGFR-TKI ( epidermal growth factor receptor tyrosine kinase inhibitor ) gefitinib [ ` Iressa ' ( trademark of the AstraZeneca group of companies ), ZD1839 ] increases the cellular uptake of radiolabelled epidermal growth factor (EGF)
Han et al., J Cell Physiol 2008 : The observations that PE induced the formation of c-Src-Stat3 binding complex and phosphorylation of epidermal growth factor receptor (EGFR) and that inhibiting Src and EGFR prevented PE-induced Stat3 activation indicate the involvement of Src and EGFR
Yavas et al., Med Hypotheses 2013 : Genomic effect induces genomic up-regulation of the EGFR protein expression via EGFR promoter, whereas nongenotropic effect leads to the EGFR transactivation resulting in persistent pathophysiological effects including formation of extracellular matrix and myocardial hypertrophy
Salvatori et al., J Cell Physiol 2009 (Osteosarcoma) : The link between the ER and EGFR pathways was confirmed by treatment with 4OH-T, which decreased the EGFR level and produced differentiation effects via ERalpha, but induced both EGFR expression and proliferation effects via ERbeta
Sundberg et al., Eur J Nucl Med Mol Imaging 2003 (Carcinoma, Squamous Cell...) : The EGFR-TKI ( epidermal growth factor receptor tyrosine kinase inhibitor ) gefitinib ( `` Iressa '', ZD1839 ), a reversible growth inhibitor of EGFR expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF
Chen et al., Cancer Res 1989 (Lung Neoplasms) : The first evidence suggesting that these two molecules are different is that the EGFR , but not gp160, is constitutively detectable in the A431 cell tissue culture supernatant, and that a pulse of these cells with epidermal growth factor ( under conditions which permit the internalization of the receptor-ligand complexes ) significantly reduces the expression of the EGFR without noticeably affecting the level of gp160 on the cell surface
Haber et al., Cold Spring Harb Symp Quant Biol 2005 (Carcinoma, Non-Small-Cell Lung...) : Molecular targeted therapy of lung cancer : EGFR mutations and response to EGFR inhibitors
Brevet et al., Lung Cancer 2011 (Adenocarcinoma...) : Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors
Marciniak et al., Mol Cancer Ther 2004 (Prostatic Neoplasms) : We reported that EGFR related peptide (ERRP) , a recently isolated negative regulator of EGFR , could be a potential therapeutic agent for colorectal cancer
Landreth et al., J Cell Biol 1985 (Carcinoma, Squamous Cell) : These data suggest that the structural association of the EGF-R may play a role in cellular processing of the hormone, as well as in regulation of the EGF-R kinase activity and in specifying its cellular substrates
Zhang et al., Biochem J 2003 : Indeed, Grb2 inhibits the interaction between Stat3 and EGFR by competitive binding to the EGFR
Wang et al., Hum Mol Genet 2010 (Prostatic Neoplasms) : In contrast, resveratrol directly binds epidermal growth factor receptor (EGFR) rapidly inhibiting EGFR phosphorylation, resulting in decreased AKT phosphorylation, in an AR-independent manner
Poppleton et al., Arch Biochem Biophys 2000 : A peptide betaIII-2 corresponding to amino acids Arg259-Lys273 in the beta2-adrenergic receptor which competes for association of Galpha ( s ) with the EGFR and increases protein tyrosine kinase activity of the EGFR could mimic the effects of EGFR-13
Schäfer et al., Oncogene 2004 (Neoplasm Invasiveness...) : Moreover, we report that the EGFR transactivation signal involves the EGFR ligands amphiregulin, HB-EGF and TGFalpha as well as the metalloproteinases ADAM 10, 15 and 17, depending on the cellular system
McCole et al., J Biol Chem 2007 : We have previously shown that EGFR negatively regulates epithelial chloride secretion as a result of transforming growth factor-alpha mediated EGFR transactivation in response to muscarinic GPCR activation
He et al., American journal of physiology. Renal physiology 2013 (Acute Kidney Injury) : Here we investigated whether epidermal growth factor receptor (EGFR) mediates this process in a murine model of folic acid ( FA ) -induced AKI using waved-2 mice that have reduced tyrosine kinase activity of EGFR and gefitinib, a specific EGFR inhibitor
Bouali et al., Oncol Rep 2009 (Prostatic Neoplasms) : Overexpression of epidermal growth factor receptor (EGFR) and mutation of pten tumor suppressor gene in human cancer cells leads to activated EGFR downstream signaling including PI3-kinase/AKT (PI3K/AKT) and/or mitogen activated protein kinases ( RAS/RAF/MAPK ) and have been linked to resistance to anti-EGFR targeted therapies
Shida et al., Cancer Res 2005 (MAP Kinase Signaling System...) : We also revealed that tyrosine phosphorylation of EGFR induced by leptin was significantly attenuated by two inhibitors, an EGFR tyrosine kinase inhibitor, AG1478, and a broad-spectrum matrix metalloproteinase inhibitor, GM6001
Kim et al., Cell Signal 2009 (Breast Neoplasms) : EGF also induced the phosphorylation of EGFR , ERK, and STAT-3, and these effects were inhibited by the EGFR inhibitor, AG1478.To investigate the involvement of the STAT-3 pathway on EGF induced MMP-9 expression, we pretreatedSKBR3 cells with JAK1, JAK2, and JAK3 inhibitors prior to EGF treatment