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EGFR — PRKCA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EGFR → PRKCA (directlyIncreases, EGFR Activity)
  Evidence: 85012702;15302935;6090944;1860884;3379075
• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: EGF/EGF-R complex (EGF-EGFR) → PKC (PRKCA/PRKCB1) (translocation, collaborate)
• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: PKC (PRKCA/PRKCB1) → EGF/EGF R complex (EGF-EGFR) (translocation, activates)
  
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: PKC alpha (PRKCA) → EGF/EGFR complex (EGF-EGFR) (modification, activates)
  Rabinovitz et al., J Cell Biol 1999*, Mainiero et al., J Cell Biol 1996*
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKCA — EGFR (physical association, affinity chromatography technology) Gauthier et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: PRKCA — EGFR (direct interaction, enzymatic study) Kochs et al., Eur J Biochem 1993*
• IRef Hprd Interaction: PRKCA — EGFR (in vivo) Gauthier et al., Biochem Biophys Res Commun 2003*
• IRef Hprd Interaction: PRKCA — EGFR (in vitro) Gauthier et al., Biochem Biophys Res Commun 2003*
• IRef Ophid Interaction: PRKCA — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., Cancer Res 2007 (Carcinoma, Squamous Cell) : GM3- and CD82 induced inhibition of EGFR signaling requires PKC-alpha translocation and serine/threonine phosphorylation, which eventually triggers EGFR Thr654 phosphorylation and receptor internalization ... Disruption of the membrane with methyl-beta-cyclodextrin dissociates the EGFR/GM3/caveolin-1/CD82/PKC-alpha complex and prevents the inhibitory effect of PKC-alpha on EGFR phosphorylation, suggesting that caveolin-1, CD82, and ganglioside interact with EGFR and PKC-alpha within intact cholesterol enriched membrane microdomains
Wang et al., Toxicol Appl Pharmacol 2009 : Inhibition of SFK or PKCalpha activities did not affect EGFR phosphorylation, while knockdown of EGFR blocked SFK phosphorylation and PKCalpha activation following Pb. Together, these results indicate that immediate activation of EGFR in response to Pb is obligatory for activation of SFK and PKCalpha and subsequent the Ras-Raf-1-MKK1/2-ERK1/2 signaling cascade
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways
Fitzer-Attas et al., FEBS Lett 1994 : In these cells over-expression of PKC-alpha reduced the expression of epidermal growth factor (EGF) receptor molecules [ ( 1990 ) J. Biol. Chem. 265, 13290-13296 ]