Gene interactions and pathways from curated databases and text-mining

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EGR1 — OPN1LW

Text-mined interactions from Literome

Miller et al., Mol Cell Biol 2012 : While GNRH mediated phosphorylation of CBP at Ser436 increased the interaction with Egr-1 on the Lhb promoter, loss of this phosphorylation site eliminated GNRH mediated Lhb expression in LßT2 cells ... Our results show that GNRH mediated phosphorylation of CBP at Ser436 is required for Egr-1 to activate Lhb expression and is a requirement for normal fertility in female mice
Webster et al., J Biol Chem 2013 : TNF, acting via NF-?B, did not change the levels of CREB, Sp1, or Egr-1 binding to the Ga ( s ) promoter, but it induced a significant reduction in the level of CBP