de Breyne et al., RNA 2008
:
Toeprinting analysis revealed that eIF1A stabilized 48S complexes, whereas eIF1 induced conformational changes in the 40S subunit, likely corresponding to partial opening of the entry latch of the mRNA binding channel, that were exacerbated by eIF3 and suppressed by eIF1A
Singh et al., Mol Cell Biol 2012
:
Sequential eukaryotic translation initiation factor 5 ( eIF5 ) binding to the charged disordered segments of eIF4G and eIF2ß stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode