Gene interactions and pathways from curated databases and text-mining

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ETS1 — FGF4

Text-mined interactions from Literome

Münchberg et al., Mech Dev 1999 : Expression of the dominant negative FGF receptor mutant in animal caps and embryos blocks XER81 transcription, arguing that the expression of this Ets gene requires active FGF signaling
Bertrand et al., Cell 2003 : Ets1/2 mediates general FGF responsiveness, while the restricted activity of GATAa targets the neural program to the ectoderm
Beh et al., Development 2007 : In ascidian embryos, FGF/MAPK mediated activation of the transcription factor Ets1/2 is required for heart tissue specification and cell migration
Ekerot et al., Biochem J 2008 : Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
Mao et al., Dev Cell 2009 (Polydactyly) : Here, we show that FGF dependent activation of the ETS transcription factors Etv4 and Etv5 contributes to proximal-distal limb outgrowth
Woznica et al., Dev Biol 2012 : The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase ( FGF/MapK ) activation of the transcription factor Ets1/2 ( Ets )
Samakovlis et al., Development 1996 : We further show that the breathless FGF receptor, a tracheal gene required for primary branching, is also required to activate expression of markers involved in secondary branching and that the pointed ETS-domain transcription factor is required for secondary branching and also to activate expression of terminal branch markers
Schweppe et al., J Biol Chem 1997 : However, overexpression of Ets-1 and GHF-1, which potentiate the Ras response, inhibits FGF stimulation of the rPRL promoter, implying that Ras and FGF signaling pathways target distinct factors to elicit their effects