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ETS1 — IL8
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Delgado et al., J Biol Chem 1999
:
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide
inhibit interleukin-12 transcription by regulating nuclear factor kappaB and
Ets activation
Qiao et al., Neoplasia (New York, N.Y.) 2007
(Neuroblastoma) :
Conversely, silencing of
Ets1 resulted in a significant decrease in
IL-8 secretion in SK-N-SH cells ... Our findings demonstrate that GRP upregulates proangiogenic
IL-8 expression in an
Ets1 dependent manner, suggesting a critical role of this process during GRP induced neuroblastoma angiogenesis and metastasis
Lee et al., Oncol Res 2013
(Adenocarcinoma...) :
We investigated the
role of HGF induced activation of GRP and
Ets-1 transcription factor in expression of the proangiogenic factor
IL-8 ... A
role for
Ets-1 in HGF induced upregulation of
IL-8 was determined by knockdown of Ets-1 with Ets-1 sh-RNA and a chromatin immune precipitation assay ... HGF induced upregulation of
IL-8 was
repressed by
Ets-1 knockdown ... We confirmed the functional
role of HGF induced
Ets-1 in activation of the
IL-8 promoter by the reporter gene assay
Sangiovanni et al., PloS one 2013
:
ETs inhibited
IL-8 secretion induced by TNF-a and IL-1ß at low concentrations ( IC50 range of 0.7-4 µg/mL )
Gri et al., J Biol Chem 1998
(Cell Transformation, Viral) :
Synergistic
regulation of the human
interleukin-12 p40 promoter by NFkappaB and
Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages