Darmoul et al., Am J Pathol 2003
(Colonic Neoplasms) :
3 ) PAR-1 activation by thrombin or AP1 led to a two-fold increase in cell motility of wounded HT29-D4
Wang et al., Biochem J 2007
:
JNK2 and JNK3 isoforms were both activated by PAR-1 and essential for chemokine GRO/CINC-1 secretion, whereas PAR-1 mediated JNK1 activation was mainly responsible for c-Jun phosphorylation, which was not involved in GRO/CINC-1 release
Brown et al., Life Sci 1997
(Cardiomegaly) :
In contrast the thrombin receptor , which also couples to phospholipase C, is strongly mitogenic and induces AP-1 dependent gene expression