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FASLG — PLA2G1B

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Chen et al., J Cell Biochem 2009 (Neuroblastoma) : Deprivation of catalytic activity could not diminish PLA(2) induced cell death and Fas/FasL upregulation
Liu et al., J Cell Physiol 2009 (MAP Kinase Signaling System) : Block of p38 MAPK by SB202190 abolished PLA(2) induced Fas/FasL upregulation and ERK inactivation, but not ROS generation ... Deprivation of catalytic activity with PLA(2) blocked completely PLA(2) induced Fas/FasL upregulation
Chen et al., J Cell Biochem 2009 (Calcium Signaling...) : Unlike PLA(2), catalytically inactive PLA(2) treatment did not markedly increase Fas and FasL protein expression, and p38 MAPK activation was exclusively responsible for catalytically inactive PLA(2) induced increase in Fas and FasL protein expression ... Unlike arachidonic acid, lysophosphatidylcholine mimicked the PLA(2) action in inducing Fas/FasL upregulation ... Together with the previous finding that c-Jun and ATF-2 are involved in transcriptional regulation of Fas and FasL, our data suggest that PLA(2) induces Fas and FasL upregulation through p38 alpha MAPK/ATF-2 and JNK1/c-Jun pathways in K562 cells, and PLA(2) catalytic activity is involved in this action
Chen et al., J Cell Biochem 2010 (Leukemia) : SB202190 ( p38 MAPK inhibitor ) pretreatment enhanced cytotoxic effect of PLA(2) and led to prolonged JNK activation, but failed to affect PLA(2) induced upregulation of Fas and FasL protein expression