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FGF16 — FGF21

Text-mined interactions from Literome

Kurosu et al., J Biol Chem 2007 : Accordingly, FGF19, but not FGF21 , activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kharitonenkov et al., J Cell Physiol 2008 : Interestingly, FGF-21 mediated effects are heparin independent suggesting that betaKlotho plays a role in FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs
Lü et al., Chin Med J (Engl) 2010 (Coronary Artery Disease) : Furthermore, FGF21 levels increased by 200 µmol/L bezafibrate could reduce CMECs apoptosis, and inhibit FGF21 expression by shRNA induced apoptosis ( P < 0.05 )
Adams et al., PloS one 2012 : The scaffold protein ßklotho ( KLB ) has previously been demonstrated in vitro to function as a co-factor permitting FGF21 mediated FGF receptor activation