Gene interactions and pathways from curated databases and text-mining

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FGF2 — SP1

Text-mined interactions from Literome

Ishibashi et al., Nihon Ganka Gakkai Zasshi 1999 (Diabetic Retinopathy...) : AGEs and basic fibroblast growth factor (bFGF) induced expression of KDR in REC, and a transcription factor Sp 1 was involved in this process
Bonello et al., J Biol Chem 2004 : FGF-2 stimulated Sp1 phosphorylation in an ERK1/2- but not p38 dependent manner, the growth factor enhancing Sp1 interaction with the PDGFR-alpha promoter
Jimenez et al., Cardiovasc Res 2004 : Overexpression of Egr-1 and Sp1 increased -1058FGF-2p.luc expression by 4.4- and 8.7-fold, respectively
Wang et al., J Cell Biochem 2010 : We next investigated the signaling pathway that mediated the effect of bFGF on TSP50 transcription, and identified that bFGF induced the phosphorylation of ERK and Sp1