Gene interactions and pathways from curated databases and text-mining

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FGF21 — PIK3CA

Text-mined interactions from Literome

Koyama et al., Dev Growth Differ 2008 : However, FGF7 and FGF10 stimulated phosphorylation of both PLCgamma1 and PI3K , but elicited only minimal phosphorylation of ERK-1/2
Lawson et al., Proc Natl Acad Sci U S A 2010 (Disease Models, Animal...) : Stromal induction of FGF signaling, increased expression of the ETS family transcription factor ERG1, and constitutive activation of PI3K signaling were evaluated
Dey et al., Cancer Res 2010 (Lung Neoplasms...) : Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
Kong et al., Eur J Pharmacol 2013 (Diabetes Mellitus) : Additionally, we found that FGF21 induced PKC?/? phosphorylation in a PI3K dependent manner ; and that a non-isoform selective PKC inhibitor blocked FGF21 inhibition of glucose production, while an inhibitor of classical and novel PKC isoforms had no effect on FGF21 inhibitory activity