Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pieretti-Vanmarcke et al., Proc Natl Acad Sci U S A 2006 (Ovarian Neoplasms) : Because MIS releases FK506 binding protein ( FKBP12 ), which activates the mammalian target of rapamycin (mTOR) downstream of Akt, rhMIS and rapamycin combinations were tested
Yoon et al., J Biol Chem 2011 : This leads to PA antagonizing FKBP38 inhibition of mTORC1 kinase activity in vitro and rescuing mTORC1 signaling from FKBP38 in cells
Dunlop et al., Cell Signal 2009 : We found that FKBP38 inhibits mTOR ( L1460P ), while the mTOR ( E2419K ) kinase domain mutant was resistant to FKBP38 inhibition ... Finally, we show that activation of mTORC1 by both Rheb and RhebL1 is impaired by FKBP38
Wang et al., J Biol Chem 2008 : Furthermore, FKBP38 did not inhibit mTORC1 signaling ... Our data also indicate that, in the mammalian cell lines tested here, neither TCTP nor FKBP38 regulates mTORC1 signaling
Peng et al., J Biol Chem 2010 : Overexpression of NS5A and FKBP38 mutants or FKBP38 knockdown revealed this mTOR activation was dependent on NS5A-FKBP38 interaction ... Additionally, NS5A or FKBP38 mutants recovered the mTOR-FKBP38 interaction ; this indicated that the impairment of mTOR-FKBP38 association was dependent on NS5A-FKBP38 binding
Uhlenbrock et al., FEBS Lett 2009 : Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation