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FOXO6 — MTOR
Text-mined interactions from Literome
White et al., Mol Cell Endocrinol 2013 :
Akt signaling can control skeletal muscle mass through
mTOR regulation of protein synthesis and
FoxO regulation of protein degradation, and this pathway has been previously identified as a target of androgen signaling
Chen et al., Dev Cell 2010 :
Thus, under stress conditions,
FoxO inhibits the anabolic activity of
mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Melnik et al., Exp Dermatol 2013 :
This hypothesis postulates that antiacne agents either enhance nuclear
FoxO activity or
inhibit mTORC1